Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

PMID:10655492

Pho86p, an endoplasmic reticulum (ER) resident protein in Saccharomyces cerevisiae, is required for ER exit of the high-affinity phosphate transporter Pho84p.

Pho86 is an ER resident required for Pho84 ER exit and COPII packaging, while Pho84 is the phosphate transporter.

"Moreover, Pho84p is localized to the endoplasmic reticulum (ER) and fails to be targeted to the plasma membrane in the absence of Pho86p. Utilizing an in vitro vesicle budding assay, we demonstrate that Pho86p is required for packaging of Pho84p into COPII vesicles."

PMID:15623581

Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER.

Pho86 is one of the specialized ER membrane chaperones that prevents aggregation of cognate polytopic clients.

"Specialized membrane-localized chaperones prevent aggregation of polytopic proteins in the ER."

PMID:16429126

Proteome survey reveals modularity of the yeast cell machinery.

High-throughput interaction evidence is not specific enough to define PHO86 molecular function.

"Proteome survey reveals modularity of the yeast cell machinery."

PMID:18467557

An in vivo map of the yeast protein interactome.

Large-scale interactome evidence supports physical association context but not a standalone protein binding function.

"An in vivo map of the yeast protein interactome."

PMID:26928762

One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy.

High-throughput localization data support ER localization.

"One library to make them all"

PMID:27107014

An inter-species protein-protein interaction network across vast evolutionary distance.

Cross-species interaction data are too generic for accepting protein binding as a core PHO86 function.

"An inter-species protein-protein interaction network"

PMID:37968396

The social and structural architecture of the yeast protein interactome.

Interactome data support broad association context but not a specific molecular-function annotation.

"The social and structural architecture of the yeast protein interactome."

file:yeast/PHO86/PHO86-deep-research-falcon.md

Falcon deep research report on PHO86

Falcon synthesis identifies Pho86 as an ER-resident transporter-specific chaperone required for Pho84 ER exit.

"PHO86 encodes an ER-resident membrane protein required for ER exit of the high-affinity phosphate transporter Pho84."