GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000024
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000113
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10987820
Tau promoter confers neuronal specificity and binds Sp1 and AP-2.
PMID:11278550
A family of AP-2 proteins down-regulate manganese superoxide dismutase expression.
PMID:11447109
Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis.
PMID:11694877
Cardiac malformations, adrenal agenesis, neural crest defects and exencephaly in mice lacking Cited2, a new Tfap2 co-activator.
PMID:12072434
Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo.
PMID:12586840
Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2.
PMID:16236267
Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.
PMID:17318229
Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation.
PMID:18718911
Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter.
PMID:19115315
The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation.
PMID:19578371
BCOR regulates mesenchymal stem cell function by epigenetic mechanisms.
PMID:1998122
Characterization of a dimerization motif in AP-2 and its function in heterologous DNA-binding proteins.
PMID:20066163
AP-2alpha Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes.
PMID:20607706
AP2 transcription factor induces apoptosis in retinoblastoma cells.
PMID:20808827
Expression of human frataxin is regulated by transcription factors SRF and TFAP2.
PMID:21084835
Dual association by TFAP2A during activation of the p21cip/CDKN1A promoter.
PMID:21204207
Genotype-phenotype analysis of the branchio-oculo-facial syndrome.
PMID:24835590
Sumoylation pathway is required to maintain the basal breast cancer subtype.
PMID:25416956
A proteome-scale map of the human interactome network.
PMID:25609649
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
PMID:28473536
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
PMID:28514442
Architecture of the human interactome defines protein communities and disease networks.
PMID:31146003
Androgen upregulates NR4A1 via the TFAP2A and ETS signaling networks.
PMID:31515488
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
PMID:33000225
KCTD1 mutants in scalp‑ear‑nipple syndrome and AP‑2α P59A in Char syndrome reciprocally abrogate their interactions, but can regulate Wnt/β‑catenin signaling.
PMID:33961781
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
PMID:7555706
Cloning and characterization of a second AP-2 transcription factor: AP-2 beta.
PMID:7559606
Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression.
PMID:8321221
An alternatively spliced mRNA from the AP-2 gene encodes a negative regulator of transcriptional activation by AP-2.
PMID:9520389
Derepression of the C/EBPalpha gene during adipogenesis: identification of AP-2alpha as a repressor.
Reactome:R-HSA-8864278
AP-2 (TFAP2) transcription factors form homo- and heterodimers
Reactome:R-HSA-8864307
TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP
Reactome:R-HSA-8864343
KCTD1 binds TFAP2 homo- and heterodimers
Reactome:R-HSA-8864381
TFAP2A,TFAP2C homodimers bind ESR1 promoter
Reactome:R-HSA-8864412
TFAP2A,TFAP2C homodimers bind the CGA gene
Reactome:R-HSA-8864426
TFAP2A,TFAP2C homodimers bind the CGB gene promoter
Reactome:R-HSA-8864453
TFAP2A,(TFAP2B,TFAP2C) homo- and heterodimers bind the ERBB2 gene promoter and recruit YY1
Reactome:R-HSA-8864690
TFAP2A,(TFAP2B) homodimers bind the KIT gene promoter
Reactome:R-HSA-8864718
TFAP2A,TFAP2C homodimers:CITED2 binds PITX2 gene promoter
Reactome:R-HSA-8864737
TFAP2A homodimer binds the VEGFA gene promoter
Reactome:R-HSA-8864989
TFAP2A homodimer binds the TGFA gene promoter
Reactome:R-HSA-8865244
TFAP2A homodimer binds CDKN1A (p21) gene
Reactome:R-HSA-8869542
TFPA2A homodimer and NPM1 bind the HSPD1 gene promoter
Reactome:R-HSA-8869543
TFPA2A homodimer and NPM1 bind the NOP2 gene promoter
Reactome:R-HSA-8869549
TFPA2A homodimer and NPM1 bind the MYBL2 gene promoter
Reactome:R-HSA-8869568
NPM1 binds TFAP2A homodimer
Reactome:R-HSA-8869575
TFAP2A in complex with DEK binds the APOE gene promoter
Reactome:R-HSA-8869580
DEK binds TFAP2A homodimers
Reactome:R-HSA-9768288
RB1 and TFAP2A bind CDH1 gene promoter
Reactome:R-HSA-9836270
TFAP2A binds TFAP2C
Reactome:R-HSA-9836275
TFAP2A binds TFAP2B
Reactome:R-HSA-9907144
MITF-M dimer and TFAP2A bind intronic elements in the IRF4 gene
PMID:12397104
Amphioxus and lamprey AP-2 genes: implications for neural crest evolution and migration patterns.
PMID:12511599
Induction of neural crest in Xenopus by transcription factor AP2alpha.
PMID:21169220
Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network.
PMID:31848212
Heterodimerization of TFAP2 pioneer factors drives epigenomic remodeling during neural crest specification.
PMID:14534133
lockjaw encodes a zebrafish tfap2a required for early neural crest development.
PMID:14985255
Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function.
PMID:17258188
Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos.
PMID:14975722
Wnt1-Cre-mediated deletion of AP-2alpha causes multiple neural crest-related defects.
PMID:21963426
Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population.
PMID:23382213
Inhibition of neural crest formation by Kctd15 involves regulation of transcription factor AP-2.
PMID:17724731
Tfap2 transcription factors in zebrafish neural crest development and ectodermal evolution.
PMID:18423521
TFAP2A mutations result in branchio-oculo-facial syndrome.
PMID:8622766
Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2.
PMID:8622765
Transcription factor AP-2 essential for cranial closure and craniofacial development.
PMID:1989904
Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis.
file:human/TFAP2A/TFAP2A-deep-research-falcon.md
Deep research report on TFAP2A (Falcon)
file:human/TFAP2A/TFAP2A-uniprot.txt
UniProt entry P05549 (TFAP2A_HUMAN)