Gene Ontology annotation through association of InterPro records with GO terms.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Combined Automated Annotation using Multiple IEA Methods.
Identification of a new caspase homologue: caspase-14.
No death without life: vital functions of apoptotic effectors.
Expression of caspase-14 and keratin-19 in the human epidermis and appendages during fetal skin development.
Mesotrypsin and caspase-14 participate in prosaposin processing: potential relevance to epidermal permeability barrier formation.
A proteome-scale map of the human interactome network.
Cytoplasmic proteases cleave Profilaggrin producing Filaggrin
Deep research summary for CASP14
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CASP14 is a non-apoptotic caspase essential for keratinocyte terminal differentiation and cornification
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Primary physiological substrate is profilaggrin/filaggrin, which is cleaved to generate natural moisturizing factors
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CASP14 also cleaves ICAD to facilitate DNA degradation during cornification
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Loss of CASP14 causes autosomal recessive congenital ichthyosis (ARCI12) with impaired skin barrier function
Deep research report on CASP14