Annotation inferences using phylogenetic trees
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
An update on molecular cat allergens: Fel d 1 and what else? Chapter 1: Fel d 1, the major cat allergen.
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Fel d 1 is a secreted secretoglobin (not a lipocalin) and the major cat allergen; its endogenous biological function is still unknown.
"The biological function of Fel d 1 is still unknown"
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Sebaceous glands, rather than saliva, are the main production site of Fel d 1.
"It is now recognized that the sebaceous glands, and not saliva, are the main production site"
The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family.
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Fel d 1 is an all-alpha secretoglobin structurally similar to uteroglobin, with an internal asymmetric cavity that could bind an amphipathic endogenous ligand.
"Fel d 1 that could bind an endogenous ligand"
Structural characterization of the tetrameric form of the major cat allergen Fel d 1.
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The Fel d 1 (1+2) tetramer crystal structure reveals two distinct calcium-binding sites; PLA2 modulation via calcium sequestration is speculated by analogy to uteroglobin.
"structure of tetrameric Fel d 1 reveals two different calcium-binding sites"
Allergens as immunomodulatory proteins: the cat dander protein Fel d 1 enhances TLR activation by lipid ligands.
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Fel d 1 binds the TLR4 agonist LPS and substantially enhances signaling through TLR4 and TLR2 via a lipid-transfer (CD14/MD2-dependent) mechanism.
"bind to the TLR4 agonist LPS"
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Fel d 1 enhances TLR4/TLR2 innate immune signaling in response to lipid ligands.
"enhances signaling through the innate receptors TLR4 and TLR2"
Molecular diagnosis in cat allergy.
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Fel d 1 binds fatty acids and steroids with good affinity, the best ligands being lauric acid and androsterone (a volatile steroid pheromone).
"binding with good affinity to some fatty acids and steroids, the best ligands being lauric acid"
The major cat allergen, Fel d 1, in diagnosis and therapy.
Falcon deep research report for CH1 (Fel d 1 chain 1)