Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.
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IRF8/ICSBP binds to the interferon consensus sequence (ICS)
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Acts as a transcriptional repressor of ICS-containing promoters
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DNA binding requires the N-terminal domain
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Expressed in hematopoietic cells
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IFN treatment alleviates repression
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
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High-throughput interactome mapping study (HI5)
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IRF8 was one of many proteins analyzed
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Study focused on innate immunity network
Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation.
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K108E mutation causes loss of nuclear localization
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K108E mutation causes loss of transcriptional activity
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IRF8 localizes to cytoplasm in resting cells
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IRF8 translocates to nucleus upon IFN-gamma stimulation
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K108E causes increased ubiquitination and proteasomal degradation
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Loss of both activator and repressor functions in mutant
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
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Systematic SELEX study of 542 human TFs
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Determined DNA binding specificities
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IRF8 included in the analysis
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
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High-throughput interactome study focused on neurodegeneration
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IRF8 was one of many proteins in the network
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Not specifically relevant to IRF8 core function
Constrained chromatin accessibility in PU.1-mutated agammaglobulinemia patients.
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IRF8 interacts with PU.1/SPI1
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PU.1 and IRF8 cooperate in chromatin accessibility
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Important for B cell development
Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene.
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IRF8/ICSBP knockout mice have immunodeficiency
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Enhanced susceptibility to viral infections
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Impaired IFN-gamma production
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Deregulated hematopoiesis with CML-like syndrome
Expression of IFN-induced genes
Expression of IFNG-stimulated genes
Deep research report on IRF8