Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A novel member of the F-box/WD40 gene family, encoding dactylin, is disrupted in the mouse dactylaplasia mutant.
Homodimer of two F-box proteins betaTrCP1 or betaTrCP2 binds to IkappaBalpha for signal-dependent ubiquitination.
The novel human DNA helicase hFBH1 is an F-box protein.
Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.
NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.
CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
TIP120A associates with cullins and modulates ubiquitin ligase activity.
Parkin is a component of an SCF-like ubiquitin ligase complex and protects postmitotic neurons from kainate excitotoxicity.
The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes.
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region.
Systematic analysis and nomenclature of mammalian F-box proteins.
Structure of the Cand1-Cul1-Roc1 complex reveals regulatory mechanisms for the assembly of the multisubunit cullin-dependent ubiquitin ligases.
Myxoma virus M-T5 protects infected cells from the stress of cell cycle arrest through its interaction with host cell cullin-1.
Characterization of FBX25, encoding a novel brain-expressed F-box protein.
Proteasomal degradation of the multifunctional regulator YB-1 is mediated by an F-Box protein induced during programmed cell death.
Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrate.
Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein.
FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity.
Impaired DNA damage checkpoint response in MIF-deficient mice.
CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha.
SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.
Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species.
Diversity in tissue expression, substrate binding, and SCF complex formation for a lectin family of ubiquitin ligases.
Phosphorylation of Skp2 regulated by CDK2 and Cdc14B protects it from degradation by APC(Cdh1) in G1 phase.
Identification of conjugation specificity determinants unmasks vestigial preference for ubiquitin within the NEDD8 E2.
Ribosomal proteins are targets for the NEDD8 pathway.
Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.
Poxvirus ankyrin repeat proteins are a unique class of F-box proteins that associate with cellular SCF1 ubiquitin ligase complexes.
Autoinhibitory regulation of SCF-mediated ubiquitination by human cullin 1's C-terminal tail.
UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.
Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation.
Structural and functional coupling of Hsp90- and Sgt1-centred multi-protein complexes.
SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
Multiple isoforms of beta-TrCP display differential activities in the regulation of Wnt signaling.
Defining the human deubiquitinating enzyme interaction landscape.
The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes.
Regulation of nucleolar signalling to p53 through NEDDylation of L11.
An E3 ligase possessing an iron-responsive hemerythrin domain is a regulator of iron homeostasis.
Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates.
Structural insights into the COP9 signalosome and its common architecture with the 26S proteasome lid and eIF3.
Lamin A rod domain mutants target heterochromatin protein 1alpha and beta for proteasomal degradation by activation of F-box protein, FBXW10.
SCF(Cyclin F) controls centrosome homeostasis and mitotic fidelity through CP110 degradation.
Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.
CSN complex controls the stability of selected synaptic proteins via a torsinA-dependent process.
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
SCFFBXL¹⁵ regulates BMP signalling by directing the degradation of HECT-type ubiquitin ligase Smurf1.
The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication.
A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases.
COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.
The glomuvenous malformation protein Glomulin binds Rbx1 and regulates cullin RING ligase-mediated turnover of Fbw7.
NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.
Mediator acts upstream of the transcriptional activator Gal4.
Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair.
F-box protein FBXL19-mediated ubiquitination and degradation of the receptor for IL-33 limits pulmonary inflammation.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
FBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells.
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma.
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.
FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.
A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation.
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.
Myeloma overexpressed 2 (Myeov2) regulates L11 subnuclear localization through Nedd8 modification.
TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
Oncogenic function of SCCRO5/DCUN1D5 requires its Neddylation E3 activity and nuclear localization.
Phosphorylation of cyclin Y by CDK14 induces its ubiquitination and degradation.
Structure of a RING E3 trapped in action reveals ligation mechanism for the ubiquitin-like protein NEDD8.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
Structural mechanism of nuclear transport mediated by importin β and flexible amphiphilic proteins.
Cyclin F suppresses B-Myb activity to promote cell cycle checkpoint control.
FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7.
The Human IL-22 Receptor Is Regulated through the Action of the Novel E3 Ligase Subunit FBXW12, Which Functions as an Epithelial Growth Suppressor.
Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.
DCUN1D3 activates SCFSKP2 ubiquitin E3 ligase activity and cell cycle progression under UV damage.
A High-Density Map for Navigating the Human Polycomb Complexome.
The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
Architecture of the human interactome defines protein communities and disease networks.
NOTCH2 Hajdu-Cheney Mutations Escape SCF(FBW7)-Dependent Proteolysis to Promote Osteoporosis.
FBXL13 directs the proteolysis of CEP192 to regulate centrosome homeostasis and cell migration.
Dimerization quality control ensures neuronal development and survival.
A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.
The tumor suppressor FBXO31 preserves genomic integrity by regulating DNA replication and segregation through precise control of cyclin A levels.
E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition.
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
The FBXL family of F-box proteins: variations on a theme.
KDM2B Overexpression Facilitates Lytic De Novo KSHV Infection by Inducing AP-1 Activity Through Interaction with the SCF E3 Ubiquitin Ligase Complex.
FBX4 mediates rapid cyclin D1 proteolysis upon DNA damage in immortalized esophageal epithelial cells.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
SCF(Fbxw5) targets kinesin-13 proteins to facilitate ciliogenesis.
Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
The SCF Complex Is Essential to Maintain Genome and Chromosome Stability.
Endotoxin stabilizes protein arginine methyltransferase 4 (PRMT4) protein triggering death of lung epithelia.
FBXO2/SCF ubiquitin ligase complex directs xenophagy through recognizing bacterial surface glycan.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Diverse Roles of F-BoxProtein3 in Regulation of Various Cellular Functions.
CFTR interactome mapping using the mammalian membrane two-hybrid high-throughput screening system.
The role of ubiquitination and deubiquitination in tumor invasion and metastasis.
Structure of CRL7(FBXW8) reveals coupling with CUL1-RBX1/ROC1 for multi-cullin-RING E3-catalyzed ubiquitin ligation.
Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.
Mitochondrial Fission and Fusion: Molecular Mechanisms, Biological Functions, and Related Disorders.
Identification of an E3 ligase that targets the catalytic subunit of RNA Polymerase I upon transcription stress.
The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.
A central role for regulated protein stability in the control of TFE3 and MITF by nutrients.
C-terminal amides mark proteins for degradation via SCF-FBXO31.
Multimodal cell maps as a foundation for structural and functional genomics.
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB
SCF-beta-TrCP ubiquitinylates IkB
Prolactin receptor is internalized
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex
Ubiquitination of p130 (RBL2) by SCF (Skp2)
PRLR binds SCF beta-TrCP complex
Ubiquitination of Emi1 by SCF-beta-TrCP
SCF-mediated degradation of Emi1
Phosphorylated Emi1 binds the beta-TrCP in the SCF complex
Association of Cks1 with SCF(Skp2) complex
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex
Degradation of ubiquitinated p27/p21 by the 26S proteasome
Ubiquitination of phospho-p27/p21
Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex
SCF Beta-TrCP complex binds to NFKB p50:p65: phospho IKBA complex
Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex
Degradation of ubiquitinated beta catenin by the proteasome
Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1)
p-NICD1 PEST domain mutants do not bind FBXW7
FBXW7 WD mutants do not bind NICD1
SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA
Phosphorylated BORA binds SCF-beta-TrCp1/2
SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP
beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex
SCF(beta-TrCP) ubiquitinates p-GLI1
SCF(beta-TrCP) ubiquitinates p-GLI3
SCF betaTrCP1,2 binds p-NFkB p105:TPL2:ABIN2
SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2
SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2
NEDD8 binds CUL1 (in SKP1:CUL1:FXBL5)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
Ubiquitination of phosphorylated CDC25A
SCF-FBXL7 ubiquitinates AURKA
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
SCF-FBXL18 ubiquitinates FBXL7
Formation of the SCF-FBXL7 complex
SCF(SKP2) complex binds RUNX2
SCF(SKP2) polyubiquitinates RUNX2
AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex
NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex
CAND1 binds cytosolic CRL E3 ubiquitin ligases
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2))
BACH1:FBXL17 binds SCF(SKP2) complex
NPM1-ALK fusion dimer binds SKP1:CUL1:RBX1:ZC3HC1
MAPK1 phsophorylates ZC3HCF1 in a NPM-ALK-dependent manner
NFE2L2 is ubiquitinated by BTRC:SKP1:CUL1:RBX1
BTRC binds p-S344, 347 NFE2L2
Ub,pS335,S338,T NFE2L2 is degraded
Transfer of Ub from E2 to substrate and release of E2
Release of E3 from polyubiquitinated substrate
Polyubiquitination of substrate
Interaction of E3 with substrate and E2-Ub complex
Ubiquitination of CD274 by BTRC-SCF E3-ligase complex
Ubiquitinated CD274 is degraded by the 26S proteasome
Deubiquitination of CD274
p-S184,T180-CD274 binds to BTRC-SCF E3 ubiquitin ligase complex
FBXW7 binds phosphorylated NICD1
FBXW7 mediates ubiquitination of phosphorylated NICD1
FBXW7 promotes ubiquitination of mouse p-NICD4
UniProtKB record for human CUL1 (Q13616)
Falcon deep research report for human CUL1
CUL1 curation notes
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Bare protein-binding rows were decided per reference: scaffold-demonstrating papers to GO:0160072, CDC34 to GO:0031624, ARIH1 to GO:0031625, regulator-of-CUL1 and screen papers removed as uninformative.