Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Equine herpesvirus-2 E10 gene product, but not its cellular homologue, activates NF-kappaB transcription factor and c-Jun N-terminal kinase.
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c-E10 is a caspase-recruiting domain-containing protein that interacts with components of death receptors signaling pathway and activates nuclear factor-kappaB.
BCL10 expression in normal and neoplastic lymphoid tissue. Nuclear localization in MALT lymphoma.
CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.
Bcl10 is a positive regulator of antigen receptor-induced activation of NF-kappaB and neural tube closure.
Equine herpesvirus protein E10 induces membrane recruitment and phosphorylation of its cellular homologue, bcl-10.
Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B.
CARD11 and CARD14 are novel caspase recruitment domain (CARD)/membrane-associated guanylate kinase (MAGUK) family members that interact with BCL10 and activate NF-kappa B.
Interchangeable binding of Bcl10 to TRAF2 and cIAPs regulates apoptosis signaling.
CLAN, a novel human CED-4-like gene.
CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis.
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation.
Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO.
Degradation of Bcl10 induced by T-cell activation negatively regulates NF-kappa B signaling.
The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes.
Characterization of Bcl10 as a potential transcriptional activator that interacts with general transcription factor TFIIB.
Bcl10 can promote survival of antigen-stimulated B lymphocytes.
Accumulation of BCL10 at the perinuclear region is required for the BCL10-mediated nuclear factor-kappa B activation.
A pathway for tumor necrosis factor-alpha-induced Bcl10 nuclear translocation. Bcl10 is up-regulated by NF-kappaB and phosphorylated by Akt1 and then complexes with Bcl3 to enter the nucleus.
cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas.
Adaptors discriminate mast-cell cytokine production from eicosanoid production and degranulation.
Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation.
The IRAK-1-BCL10-MALT1-TRAF6-TAK1 cascade mediates signaling to NF-kappaB from Toll-like receptor 4.
Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II.
Carrageenan induces interleukin-8 production through distinct Bcl10 pathway in normal human colonic epithelial cells.
Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1.
Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways.
Malt1 ubiquitination triggers NF-kappaB signaling upon T-cell activation.
T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20.
NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.
Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival.
COP9 signalosome controls the Carma1-Bcl10-Malt1 complex upon T-cell stimulation.
Expression of the Bcl-2 protein BAD promotes prostate cancer growth.
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.
Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.
Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.
Protein kinase C-δ negatively regulates T cell receptor-induced NF-κB activation by inhibiting the assembly of CARMA1 signalosome.
MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.
Structural architecture of the CARMA1/Bcl10/MALT1 signalosome: nucleation-induced filamentous assembly.
Charting the molecular links between driver and susceptibility genes in colorectal cancer.
Combining immunofluorescence with in situ proximity ligation assay: a novel imaging approach to monitor protein-protein interactions in relation to subcellular localization.
Inherited BCL10 deficiency impairs hematopoietic and nonhematopoietic immunity.
A proteome-scale map of the human interactome network.
Widespread macromolecular interaction perturbations in human genetic disorders.
Ubiquitin Ligase TRIM62 Regulates CARD9-Mediated Anti-fungal Immunity and Intestinal Inflammation.
Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma.
Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
Molecular Determinants of Scaffold-induced Linear Ubiquitinylation of B Cell Lymphoma/Leukemia 10 (Bcl10) during T Cell Receptor and Oncogenic Caspase Recruitment Domain-containing Protein 11 (CARD11) Signaling.
Germline hypomorphic CARD11 mutations in severe atopic disease.
CARD-BCL-10-MALT1 signalling in protective and pathological immunity.
Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Paracaspase MALT1 regulates glioma cell survival by controlling endo-lysosome homeostasis.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Multimodal cell maps as a foundation for structural and functional genomics.
CARMA1 recruits MALT1 and BCL10 forming CBM Complex
Auto-ubiquitination of TRAF6
Interaction of Bcl10 to CARMA1
Translocation of TRAF6 to CBM complex
Interaction and oligomerization of MALT1 to Bcl10
Activation of IKK complex
Activation of TAK1-TAB2 complex
Ubiquitination of NEMO by TRAF6
Recruitment of TAK1 kinase complex to oligo-K63-pUb-TRAF6
Recruitment of TRAF6 to CBM complex by binding to MALT1
Phosphorylation of IKK-beta by TAK1
Oligomerization of BCL10 and MALT1
Activation of TAK1 complex bound to pUb-TRAF6
Auto-ubiquitination of TRAF6
K63polyUb-TAK1 autophosphorylates
K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta
TRAF6 binds MALT1 oligomers
TRAF6 oligomer autoubiquitinates
K63polyUb-TRAF6 ubiquitinates TAK1
TRIKA2 binds K63polyUb-TRAF6 oligomer
RNF181 binds BCL10 and Ubiquitin:E2
RNF181 polyubiquinates BCL10
B-cell CLL/lymphoma 10 (BCL10) is required for NF-kappaB production by both canonical and noncanonical pathways and for NF-kappaB-inducing kinase (NIK) phosphorylation.
Structural basis for the lack of E2 interaction in the RING domain of TRAF2.
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2.
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling.