sma-9 notes

Deep research: the wrapper reported a falcon timeout (600 s), and the perplexity fallback was unavailable. The review relies on the cached publications and UniProt Q7JM44.

• Schnurri homolog and a downstream DBL-1 pathway component PMID:14627718
• Mainly a repressor in body size; both activator and repressor activity act in the male tail PMID:17397820
• Antagonizes BMP in the dorsal M lineage PMID:16790477 by repressing unc-130 PMID:29155044
• Annotations from PMID:25407930 (amyloid-beta model; abstract-only) cannot be verified. Lifespan, heat response and nuclear-localization rows are UNDECIDED.
• Note for the module: SMA-9 has an opposite sign in the M lineage (it antagonizes BMP), unlike its positive role in body size.

Deep research update: a falcon job eventually completed and wrote sma-9-deep-research-falcon.md. Points from it (primary papers not cached here):
- Vora et al. 2025 (eLife): SMA-9 ChIP-seq gave 7,065 peaks, 3,101 of them overlapping SMA-3. Direct targets are about equally up- and down-regulated, and most SMA-3/SMA-9 co-targets are activated by both. This tempers the 'mainly a repressor' conclusion, so a suggested question was added.
- Yin et al. 2010: a C-terminal isoform (D01) acts in ray patterning.
- Baccas et al. 2025: SMA-9 restrains SEM-2 and permits LET-381 in the dorsal M lineage.
- A review states that SMA-9 is not required for the DBL-1 antifungal AMP response.

ROS and mitochondrial UPR statements in UniProt (2026-10-30)

• UniProt FUNCTION says SMA-9 is "Involved in production of reactive oxygen species (ROS)"
  and "Plays a role in the mitochondrial unfolded protein response (mtUPR)", citing
  PubMed:20687916. That paper is Wong et al. 2010 on mab-31 and male ray patterning; its
  cached full text contains no ROS, mitochondrial or nanopolystyrene data.
• The statements match a nanopolystyrene toxicology study PMID:32758726. The
  UniProt citation looks mis-keyed; recorded as a source defect on the UniProt reference.
• The finding is a response to a xenobiotic exposure, from one abstract-only study, and is
  peripheral to SMA-9's role as a Schnurri-family BMP pathway cofactor. Not annotated.