Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
ARMC5 mutations in macronodular adrenal hyperplasia with Cushing's syndrome.
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ARMC5 is mostly cytoplasmic in adrenal tissue and cell lines.
"Immunohistochemical analysis of adrenal samples and two cell lines (H295R and HeLa) showed that ARMC5 is mostly located in the cytoplasm (Fig."
Armc5 deletion causes developmental defects and compromises T-cell immune responses.
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Yeast two-hybrid ARMC5 partners; Armc5 knockout embryonic lethality.
"We have identified a group of ARMC5-interacting proteins by yeast 2-hybrid (Y2H) assay, paving the way for further mechanistic and functional investigations of ARMC5."
A reference map of the human binary protein interactome.
ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.
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ARMC5, CUL3 and RBX1 form an RPB1-specific E3.
"Here, we show that ARMC5, CUL3 and RBX1 form an active E3 ligase complex specific for RPB1."
ARMC5-CUL3 E3 ligase targets full-length SREBF in adrenocortical tumors.
ARMC5 controls the degradation of most Pol II subunits, and ARMC5 mutation increases neural tube defect risks in mice and humans.
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ARMC5 loss stabilizes most Pol II subunits.
"Surprisingly, the absence of ARMC5 causes the accumulation of not only POLR2A but also most of the other 11 Pol II subunits, indicating that the degradation of the whole Pol II complex is compromised."
Redundant pathways for removal of defective RNA polymerase II complexes at a promoter-proximal pause checkpoint.
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CRL3-ARMC5 ubiquitylates Ser5-phosphorylated RPB1 when pause factors are defective.
"Here, we show that loss of INTS6 in human cells results in increased interaction of RNAPII with proteins that can mediate its dissociation from the DNA template, including the CRL3ARMC5 E3 ligase, which ubiquitylates CTD serine5-phosphorylated RPB1 for degradation."
CRL3(ARMC5) ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription.
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CRL3-ARMC5 targets excess and defective early Pol II, in parallel with Integrator.
"Here, we reveal a distinct ubiquitylation pathway in human cells, mediated by CRL3ARMC5, that targets excessive and defective RNA Pol II molecules at the initial stages of the transcription cycle."
Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function.
SPT5 regulates RNA polymerase II stability via Cullin 3-ARMC5 recognition.
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ARMC5 is the CUL3 adaptor for chromatin-bound, SPT5-depleted Pol II; ChIP-seq shows ARMC5 occupancy.
"Using an unbiased proteomic screening approach, we identify armadillo repeat-containing 5 (ARMC5) as a CUL3 adaptor required for VCP/p97-dependent degradation of SPT5-depleted, chromatin-bound Pol II."
Cullin 3 targets the tumor suppressor gene ARMC5 for ubiquitination and degradation.
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ARMC5 binds CUL3 via its BTB domain.
"In this study, we showed that ARMC5 interacts with CUL3 requiring its BTB domain."
ARMC5 selectively degrades SCAP-free SREBF1 and is essential for fatty acid desaturation in adipocytes.
UniProt entry Q96C12 (ARMC5_HUMAN)
Affinage mechanistic annotation for ARMC5 (human)