Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
Coupling between d-3-phosphoglycerate dehydrogenase and d-2-hydroxyglutarate dehydrogenase drives bacterial l-serine synthesis.
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A bacterial FAD-dependent D-2-hydroxyglutarate dehydrogenase converts D-2-HG to 2-oxoglutarate and is functionally tied to L-serine synthesis.
"d-2-HG dehydrogenase (D2HGDH), a flavin adenine dinucleotide (FAD)-dependent"
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Deleting D2HGDH decreases growth, rescued by L-serine.
"while the mutant with D2HGDH deletion displayed decreased growth"