Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.
The regulated association of Cdt1 with minichromosome maintenance proteins and Cdc6 in mammalian cells.
Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.
Self-assembling protein microarrays.
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis.
Cdt1 associates dynamically with chromatin throughout G1 and recruits Geminin onto chromatin.
Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing.
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6.
A WD-repeat protein stabilizes ORC binding to chromatin.
Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress.
Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment.
The histone demethylase LSD1/KDM1A promotes the DNA damage response.
Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architecture.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.
Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
USP37 deubiquitinates Cdt1 and contributes to regulate DNA replication.
Architecture of the human interactome defines protein communities and disease networks.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7
Cdt1 is displaced from the pre-replicative complex
Orc1 is phosphorylated by cyclin A/CDK2
CDT1 gene expression is stimulated by E2F1
Cdt1 stabilizes kinetochore-microtubule attachments via an Aurora B kinase-dependent mechanism.
Multiple mechanisms for licensing human replication origins.
Molecular impacts of Meier-Gorlin syndrome mutations on human origin licensing.
Evidence for a role of Arabidopsis CDT1 proteins in gametophyte development and maintenance of genome integrity.
Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity.
CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis.
Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini-chromosome maintenance complex and causes DNA damage.
Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions.
CDT1 source assertions and exact interaction-record evidence