elna notes

2026-09-27 (claude-opus-5-5, DANRE_DUPLICATION pair review elna/elnb)

• Accession: A0A8N1TQS2 (1164 aa, RefSeq NP_001073532, unreviewed TrEMBL). Sensible: matches
  the 101 kDa / 57-exon Elna of the review PMID:35216218.
  The PANTHER table lists A0A8M6YT25 for elna; a UniProt REST lookup of that accession on 2026-09-27 returned no record.
• GOA: only 2 InterPro2GO IEA (ECM structural constituent; ECM) and 2 root ND rows. No GOA-cited PMIDs.
• TGD origin: PMID:26783159;
  single eln in all non-teleosts PMID:41465165.
• Sequence: closer to human ELN than elnb PMID:35216218
• Expression broad, like Polypterus eln PMID:26783159.
• Loss of function: morphant swim bladder defect PMID:26783159;
  germline sa12235 (PTC Tyr88) reduces valve elastin, shortens life PMID:37408270.
  No test of elnb upregulation (transcriptional adaptation).
• Decisions: ND x2 REMOVE; GO:0005201 MODIFY -> GO:0030023; GO:0031012 ACCEPT; NEW GO:0071953 elastic fiber (IDA, PMID:17112714),
  NEW GO:0048251 elastic fiber assembly (IMP, PMID:37408270). Participation: tropoelastin is the structural monomer of the fiber.
  Comparator: mouse Eln has GO:0085029 (IMP); FBN1/FBLN5/EMILIN1/MFAP4 have GO:0048251 (QuickGO, human).
  Not added: bulbus arteriosus development (no elna BA morphology defect), valve/swim bladder process terms (adult degeneration / morphant only).
• Deep research: elna-deep-research-falcon.md present and used as a pointer (its PMIDs-backed claims re-anchored to cached papers).
• Pair page: projects/DANRE_DUPLICATION/pairs/elna_elnb/elna_elnb.md