Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells.
Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88.
Isolated Toll-like receptor transmembrane domains are capable of oligomerization.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Structural and functional understanding of the toll-like receptors.
IRAK4 deficiency blocks formation of the MyD88-IRAK4 Myddosome in the TLR5 pathway
IRAK1/or IRAK2 binds to the activated IRAK4 :oligo MyD88:activated TLR5 or 10 complex
Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR
TRAF6 binds to hp- IRAK1 or p-IRAK2
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex
IRAK4 autophosphorylation within the complex activated TLR:MyD88
MyD88 forms a complex with the activated TLR receptor
IRAK4 binds to MyD88 bound to the activated TLR5 or 10 receptor
Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex
First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR
Dissociation of hp-IRAK1:TRAF6 or IRAK2:TRAF6-oligomer from the activated TLR5 or 10:oligo-Myd88:p-IRAK4 complex
MyD88 oligomerization within the complex of activated TLR:MyD88
Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.
Human TLR10 is an anti-inflammatory pattern-recognition receptor.
TLR10 Is a Negative Regulator of Both MyD88-Dependent and -Independent TLR Signaling.
TLR10 Is a B Cell Intrinsic Suppressor of Adaptive Immune Responses.
TLR10 suppresses the activation and differentiation of monocytes with effects on DC-mediated adaptive immune responses.
TLR10 (CD290) Is a Regulator of Immune Responses in Human Plasmacytoid Dendritic Cells.
Recognition of Double-Stranded RNA and Regulation of Interferon Pathway by Toll-Like Receptor 10.
Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection.
Identification of TLR10 as a key mediator of the inflammatory response to Listeria monocytogenes in intestinal epithelial cells and macrophages.
TLR10 Senses HIV-1 Proteins and Significantly Enhances HIV-1 Infection.
Falcon deep research report on TLR10