Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Autophagy genes are essential for dauer development and life-span extension in C. elegans.
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Established LGG-1/APG8 as essential for autophagy in C. elegans
"Dauer formation is associated with increased autophagy and also requires C. elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10."
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Required for dauer development and longevity
"autophagy genes are essential for dauer development and life-span extension in C. elegans"
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GFP::LGG-1 established as autophagosome marker
"Autophagy, through the sequestration and delivery of cargo to the lysosomes, is the major route for degrading long-lived proteins and cytoplasmic organelles in eukaryotic cells."
A map of the interactome network of the metazoan C. elegans.
Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans.
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LGG-1 contributes to necrotic neurodegeneration
"Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans."
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Inactivation partially suppresses neuronal death
"Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans."
Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network.
SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans.
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LGG-1 directly binds SEPA-1 cargo receptor
"SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans."
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Required for P granule degradation in somatic cells
"SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans."
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Established selective autophagy mechanism
"SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans."
The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans.
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LGG-1 and LGG-2 have synergistic functions
"The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans."
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Both required for dauer and longevity
"The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans."
Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle.
Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans.
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Autophagy required for longevity in germline-less animals
"Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans."
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Link between autophagy and lipid metabolism
"Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans."
Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans.
TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.
Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans.
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LGG-1 interacts with AIN-1
"Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans."
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Autophagy regulates miRNA silencing
"Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans."
The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39.
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LGG-1 acts upstream of LGG-2
"The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39."
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LGG-1 required for LGG-2 recruitment to autophagosomes
"The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39."
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Established sequential roles of ATG8 paralogs
"The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39."
Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.
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HLH-30/TFEB regulates autophagy
"Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes."
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LGG-1 induced during infection
"Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes."
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.
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LGG-1 required for mitophagy
"Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans."
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DCT-1 is key mitophagy mediator
"Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans."
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LGG-1 localizes to mitochondrial outer membrane
"Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans."
Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.
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Crystal structure of LGG-1
"Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy."
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LGG-1 binds LIR motifs in cargo receptors
"Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy."
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Direct interactions with SEPA-1, SQST-1, EPG-7, ATG-13, UNC-51
"Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy."
HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans.
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LGG-1 required for xenophagy of bacterial toxins
"HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans."
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Autophagy contributes to membrane pore repair
"HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans."
Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans.
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LGG-1 induced by heat stress
"Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans."
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Required for thermoresistance and longevity
"Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans."
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Essential for hormetic heat shock benefits
"Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans."
The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans.
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LGG-1 binds ALLO-1 autophagy receptor via LIR
"The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans."
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Required for paternal mitochondrial elimination
"The autophagy receptor ALLO-1 and the IKKE-1 kinase control clearance of paternal mitochondria in Caenorhabditis elegans."
Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2.
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LGG-1 localization in neurons
"Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2."
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ATG-4.2 required for neuronal autophagy
"Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2."
LGG-1/GABARAP lipidation is not required for autophagy and development in Caenorhabditis elegans.
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C-terminal cleavage essential for autophagosome initiation
"LGG-1/GABARAP lipidation is not required for autophagy and development in Caenorhabditis elegans."
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Lipidation not strictly required for autophagy
"LGG-1/GABARAP lipidation is not required for autophagy and development in Caenorhabditis elegans."
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Lipidation enhances cargo recognition and LGG-2 formation
"LGG-1/GABARAP lipidation is not required for autophagy and development in Caenorhabditis elegans."
Differential function of the two Atg4 homologues in the aggrephagy pathway in Caenorhabditis elegans.
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ATG-4.1 and ATG-4.2 process LGG-1
"Differential function of the two Atg4 homologues in the aggrephagy pathway in Caenorhabditis elegans."
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Required for aggrephagy
"Differential function of the two Atg4 homologues in the aggrephagy pathway in Caenorhabditis elegans."
Deep research summary for LGG-1 function
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LGG-1 is the C. elegans ortholog of ATG8/LC3/GABARAP family
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Functions in autophagosome biogenesis and selective autophagy
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Participates in paternal mitochondrial elimination and nucleophagy