Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp.
The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase.
Cloning and characterization of a novel adaptor protein, CIN85, that interacts with c-Cbl.
SHP2 and cbl participate in alpha-chemokine receptor CXCR4-mediated signaling pathways.
Functional conservation of 14-3-3 isoforms in inhibiting bad-induced apoptosis.
A novel Src homology 2 domain-containing molecule, Src-like adapter protein-2 (SLAP-2), which negatively regulates T cell receptor signaling.
CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.
Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function.
Dab2 links CIN85 with clathrin-mediated receptor internalization.
Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.
CIN85 associates with multiple effectors controlling intracellular trafficking of epidermal growth factor receptors.
Engagement of beta2 integrins recruits 14-3-3 proteins to c-Cbl in human neutrophils.
LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation.
Ubiquitin ligase activity of c-Cbl guides the epidermal growth factor receptor into clathrin-coated pits by two distinct modes of Eps15 recruitment.
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells.
c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2.
Structural characterization of a novel Cbl phosphotyrosine recognition motif in the APS family of adapter proteins.
Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.
Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule betaPix.
Recruitment and activation of PLCgamma1 in T cells: a new insight into old domains.
Targeting AMAP1 and cortactin binding bearing an atypical src homology 3/proline interface for prevention of breast cancer invasion and metastasis.
A Src homology 3-binding sequence on the C terminus of Sprouty2 is necessary for inhibition of the Ras/ERK pathway downstream of fibroblast growth factor receptor stimulation.
Intersectin regulates epidermal growth factor receptor endocytosis, ubiquitylation, and signaling.
Constitutive c-jun N-terminal kinase activity in acute myeloid leukemia derives from Flt3 and affects survival and proliferation.
Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation.
Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.
Identification and functional characterization of an Src homology domain 3 domain-binding site on Cbl.
Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination.
PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases.
A critical role for the E3-ligase activity of c-Cbl in VEGFR-2-mediated PLCgamma1 activation and angiogenesis.
Abi-1 forms an epidermal growth factor-inducible complex with Cbl: role in receptor endocytosis.
The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor.
Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathway.
A novel role of Sprouty 2 in regulating cellular apoptosis.
Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates.
Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.
Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.
Charting the molecular network of the drug target Bcr-Abl.
The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Differential roles of ERK and Akt pathways in regulation of EGFR-mediated signaling and motility in prostate cancer cells.
Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis.
A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding.
A human MAP kinase interactome.
An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding.
Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl.
Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Threshold-controlled ubiquitination of the EGFR directs receptor fate.
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
RASopathy-associated CBL germline mutations cause aberrant ubiquitylation and trafficking of EGFR.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Phospho-tyrosine dependent protein-protein interaction network.
Weak binding to E3 ubiquitin ligase c-Cbl increases EGFRvA protein stability.
Architecture of the human interactome defines protein communities and disease networks.
IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A central chaperone-like role for 14-3-3 proteins in human cells.
Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs.
Multimodal cell maps as a foundation for structural and functional genomics.
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Tyrosine phosphorylation of the c-cbl proto-oncogene protein product and association with epidermal growth factor (EGF) receptor upon EGF stimulation.
The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent manner.
Stimulation through the T cell receptor induces Cbl association with Crk proteins and the guanine nucleotide exchange protein C3G.
Activation-modulated association of 14-3-3 proteins with Cbl in T cells.
Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif.
Yeast two-hybrid in vivo association of the Src kinase Lyn with the proto-oncogene product Cbl but not with the p85 subunit of PI 3-kinase.
A novel, multifuntional c-Cbl binding protein in insulin receptor signaling in 3T3-L1 adipocytes.
Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
Binding of CBL to ligand-responsive p-6Y-EGFR mutants
Inefficient ubiquitination of ligand-responsive p-6Y-EGFR mutants by p-Y371-CBL
Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants
CBL dissociates from ubiquitinated p-SPRY2
Phosphorylation of CBL (EGFR:CBL)
CBL-mediated ubiquitination of CIN85
Sprouty lures CBL away from EGFR
Sprouty sequesters CBL away from active EGFR
Ubiquitination of stimulated EGFR (CBL)
Assembly of EGFR complex in clathrin-coated vesicles
Beta-Pix:CDC42:GTP binds CBL in EGF:p-6Y-EGFR:CBL:CIN85
Ubiquitination of stimulated EGFR (CBL:GRB2)
CBL ubiquitinates Sprouty
Phosphorylation of CBL (EGFR:GRB2:CBL)
Localization of CBL:GRB2 to the membrane
EGFR non-clathrin mediated endocytosis
CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix
CBL binds and ubiquitinates phosphorylated Sprouty
CDC42:GTP binds CBL:Beta-Pix
Recruitment of CBL to KIT
EGFRvIII does not bind CBL
CBL ubiquitinates FRS2 and FGFR1
p-CBL:GRB2 binds p-FRS2:activated FGFR1
CBL ubiquitinates FRS2 and FGFR2
CBL ubiquitinates FRS2 and FGFR3
CBL ubiquitinates FRS2 and FGFR4
p-CBL:GRB2 binds p-FRS2:activated FGFR2
p-CBL:GRB2 binds p-FRS2:activated FGFR3
p-CBL:GRB2 binds p-FRS2:activated FGFR4
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Epsin family proteins bind ubiquitinated cargo
EGFR phosphorylates EPS15
EGFR binds EPS15, EPN1, EPS15L1
PTPN3 dephosphorylates EPS15
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
CBL monoubiquitinates activated MET
InlB-mediated entry of Listeria monocytogenes into host cell
CBL recruits CIN85:endophilin to ubiquitinated MET
EPS15 and HGS bind ubiquitinated MET
CBL binds InlB-activated MET
CBL monoubiquitinates InlB-bound MET
CIN85 dissociates from EGF:p-6Y-EGFR:CBL:Beta-Pix:CDC42:GTP:CIN85
Phosphorylated SPRY2 is ubiquitinated by CBL
CBL mutants don't ubiquitinate FLT3
FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl.
FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival.
The Casitas B lineage lymphoma (Cbl) mutant G306E enhances osteogenic differentiation in human mesenchymal stromal cells in part by decreased Cbl-mediated platelet-derived growth factor receptor alpha and fibroblast growth factor receptor 2 ubiquitination.
Falcon deep research report for CBL
Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl.
Cbl negatively regulates JNK activation and cell death.