ATG13 notes (human, O75143)

Deep research: not run (falcon times out after 600 s in this environment and perplexity-lite is not
installed). Review based on cached publications and the UniProt record.

Key findings

• Subunit of ULK1-ATG13-FIP200 complex PMID:19211835; on isolation membrane and essential for autophagosome formation PMID:19211835.
• Activates ULK and bridges to FIP200 PMID:19225151.
• ATG101 binds via ATG13 HORMA [PMID:19597335; PMID:26299944].
• LIR binds LC3 isoforms PMID:24290141.
• Mitophagy: recruited to damaged mitochondria after ULK1 phosphorylation PMID:21855797.
• ULK1C:PI3KC3-C1 supercomplex; contacts mainly FIP200 with VPS15/ATG14/BECN1 PMID:40442316.
• The lipidation paper itself says ATG13 "may not be essential for the lipidation of LC3" PMID:19225151.

Decisions

• Class III PI3K complex (IPI), autophagosome (IBA), regulation of protein lipidation, piecemeal microautophagy of nucleus (IBA, yeast route) and the obsolete parkin-screen term: MARK_AS_OVER_ANNOTATED.
• Obsolete PAS membrane -> MODIFY to phagophore assembly site.
• Core MF: protein kinase regulator activity (GO:0019887) in Atg1/ULK1 kinase complex, matching worm atg-13.