Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia.
The major splice variant of human 5-aminolevulinate synthase-2 contributes significantly to erythroid heme biosynthesis.
Deficiency of the ADP-forming succinyl-CoA synthase activity is associated with encephalomyopathy and mitochondrial DNA depletion.
Mitochondrial encephalomyopathy with elevated methylmalonic acid is caused by SUCLA2 mutations.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Phosphoproteome analysis of functional mitochondria isolated from resting human muscle reveals extensive phosphorylation of inner membrane protein complexes and enzymes.
N-terminome analysis of the human mitochondrial proteome.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
A reference map of the human binary protein interactome.
Tartryl-CoA inhibits succinyl-CoA synthetase.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
The immunometabolite itaconate inhibits heme synthesis and remodels cellular metabolism in erythroid precursors.
-
Recombinant SCS-A and pig heart SCS-G metabolised succinate.
"Succinate but not itaconate at 10 mM concentrations is metabolized by pig heart SCS-GTP (SCS-G) (A) and recombinant SCS-ATP (SCS-A) (B)."
-
Itaconate is not a substrate of SCS-A or pig SCS-G at 10 mM, and it inhibits the enzyme.
"neither ATP- nor GTP-specific SCS is able to use itaconate under the same conditions as succinate in vitro"
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
CLYBL averts vitamin B(12) depletion by repairing malyl-CoA.
Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes.
SUCLG1/A2 cleaves succinyl-CoA
UniProt record Q9P2R7 (SUCLA2_HUMAN)
-
UniProt records ATP-specific itaconyl-CoA and malyl-CoA synthetase activity, citing PMID:40108300.
"Also able to act as an ATP-specific itaconyl- and malyl-CoA synthetase (PubMed:40108300)."
Affinage mechanistic annotation for SUCLA2 (human)
-
SUCLA2 is the ADP-forming beta subunit of mitochondrial succinyl-CoA synthetase.
"SUCLA2 encodes the ADP-forming β subunit of mitochondrial succinyl-CoA synthetase"
-
Affinage grounds the gene partly with transferase activity and molecular function regulator activity.
"GO:0016740 transferase activity, GO:0098772 molecular function regulator activity"