Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Type 2A protein phosphatase, the complex regulator of numerous signaling pathways.
Absence of PPP2R1A mutations in Wilms tumor.
Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: evidence for a heterotrimeric form of protein phosphatase 5.
Protein phosphatase 2A interacts with and directly dephosphorylates RelA.
Galpha12 directly interacts with PP2A: evidence FOR Galpha12-stimulated PP2A phosphatase activity and dephosphorylation of microtubule-associated protein, tau.
Single-step Strep-tag purification for the isolation and identification of protein complexes from mammalian cells.
Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A.
Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II.
PP2A is required for centromeric localization of Sgo1 and proper chromosome segregation.
Interaction of nucleoredoxin with protein phosphatase 2A.
Structure of protein phosphatase 2A core enzyme bound to tumor-inducing toxins.
Structure of the protein phosphatase 2A holoenzyme.
A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.
Methylation of the C-terminal leucine residue of the PP2A catalytic subunit is unnecessary for the catalytic activity and the binding of regulatory subunit (PR55/B).
Mechanisms of the HRSL3 tumor suppressor function in ovarian carcinoma cells.
Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40.
The tumor suppressor PP2A Abeta regulates the RalA GTPase.
CIP2A inhibits PP2A in human malignancies.
Tesk1 interacts with Spry2 to abrogate its inhibition of ERK phosphorylation downstream of receptor tyrosine kinase signaling.
Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.
A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein.
An integrated workflow for charting the human interaction proteome: insights into the PP2A system.
PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma.
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.
Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells.
B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer.
ATM-mediated phosphorylation activates the tumor-suppressive function of B56γ-PP2A.
Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aα catalytic subunit.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.
An extracellular-matrix-specific GEF-GAP interaction regulates Rho GTPase crosstalk for 3D collagen migration.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
FAM122A, a new endogenous inhibitor of protein phosphatase 2A.
Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.
ARPP-16 Is a Striatal-Enriched Inhibitor of Protein Phosphatase 2A Regulated by Microtubule-Associated Serine/Threonine Kinase 3 (Mast 3 Kinase).
Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56.
Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders.
Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
A reference map of the human binary protein interactome.
INTS10-INTS13-INTS14 form a functional module of Integrator that binds nucleic acids and the cleavage module.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase.
Cryo-EM structure of the Hippo signaling integrator human STRIPAK.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Structural basis of Integrator-mediated transcription regulation.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Structural basis of INTAC-regulated transcription.
Novel Variants of PPP2R1A in Catalytic Subunit Binding Domain and Genotype-Phenotype Analysis in Neurodevelopmentally Delayed Patients.
Cryo-EM structures of PP2A:B55-FAM122A and PP2A:B55-ARPP19.
Structural basis of Integrator-dependent RNA polymerase II termination.
Multimodal cell maps as a foundation for structural and functional genomics.
Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle.
Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens.
Identification of structural elements involved in the interaction of simian virus 40 small tumor antigen with protein phosphatase 2A.
The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs.
SPRY2 translocates to the plasma membrane
SRC phosphorylates SPRY2 on Y55 and Y227
PPA2A dephosphorylates SPRY2
PPTN11 dephosphorylates SPRY2
AJUBA facilitates AURKA autophosphorylation
AJUBA binds centrosome-associated AURKA
PP2A dephosphorylates BANF1
AURKA phosphorylates PLK1
BORA binds PLK1 and AURKA
Plk1-mediated phosphorylation of Nlp
Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
Loss of C-Nap-1 from centrosomes
Dissociation of Phospho-Nlp from the centrosome
Recruitment of Plk1 to centrosomes
Association of NuMA with microtubules
Recruitment of CDK11p58 to the centrosomes
Translocation of NuMA to the centrosomes
RAB3IP stimulates nucleotide exchange on RAB8A
C2CD3 binds the mother centriole
C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole
CP110 and CEP97 dissociate from the centriole
The distal appendage proteins recruit TTBK2
Recruitment of transition zone proteins
MARK4 binds ODF2 in the centriole
CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body
TPX2 binds AURKA at centrosomes
TPX2 promotes AURKA autophosphorylation
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
SMG6 hydrolyzes mRNA with premature termination codon
SPRY2 is phosphorylated by phosphorylated MNK1