Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.
Real-time detection of interactions between the human oxytocin receptor and G protein-coupled receptor kinase-2.
Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts.
Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2).
Structure/function analysis of alpha2A-adrenergic receptor interaction with G protein-coupled receptor kinase 2.
Internalization and desensitization of the oxytocin receptor is inhibited by Dynamin and clathrin mutants in human embryonic kidney 293 cells.
Mdm2 is involved in the ubiquitination and degradation of G-protein-coupled receptor kinase 2.
Characterization of G-protein coupled receptor kinase interaction with the neurokinin-1 receptor using bioluminescence resonance energy transfer.
Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity.
G protein-coupled receptor kinase 2 positively regulates epithelial cell migration.
The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.
Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK.
Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development.
Role of the amino terminus of G protein-coupled receptor kinase 2 in receptor phosphorylation.
Defining the membrane proteome of NK cells.
Function of the cytoplasmic tail of human calcitonin receptor-like receptor in complex with receptor activity-modifying protein 2.
Regulation of C3a receptor signaling in human mast cells by G protein coupled receptor kinases.
Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis.
Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.
G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
Architecture of the human interactome defines protein communities and disease networks.
Airway smooth muscle photorelaxation via opsin receptor activation.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D(2) receptor regulation and signaling.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
GRK2 kinases in the primary cilium initiate SMOOTHENED-PKA signaling in the Hedgehog cascade.
β-Arrestin mediates the export of ciliary GPR161 but not Smoothened together with the BBSome and intraflagellar transport machinery.
Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor.
G protein-coupled receptor kinase GRK2 is a phospholipid-dependent enzyme that can be conditionally activated by G protein betagamma subunits.
GPCR downstream signalling
GRK2 sequesters activated Gq
CSNK1A1 and ADRBK1 dissociate from p-SMO dimer
ADRB2 in ADRB2:GRK complex is phosphorylated
ADBRK1,2 phosphorylate AVPR2
ADRB2:GRK complex dissociates to Phosphorylated ADRB2
GRKs bind ADRB2:Catecholamine