Gene Ontology annotation through association of InterPro records with GO terms.

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.

file:human/PHTF1/PHTF1-falcon-research.md

Deep research on PHTF1 function (earlier version)

file:human/PHTF1/PHTF1-deep-research-falcon.md

Comprehensive deep research on PHTF1 function (Falcon API)

PHTF1 is a multi-pass membrane protein, NOT a transcription factor despite its historical name
Localized to ER membrane and cis-Golgi network membrane
Candidate member of 7TMIC superfamily based on AlphaFold2 structural analysis
Interacts with FEM1B (validated by Y2H, co-IP)
Expression enriched in testis and cerebellum

file:human/PHTF1/PHTF1-uniprot.txt

UniProt entry for PHTF1 (Q9UMS5)

Multi-pass membrane protein with 8 transmembrane helices
Subcellular location annotated as ER membrane and cis-Golgi network membrane
CAUTION note explicitly states protein is NOT a transcription factor
Interacts with FEM1B

PMID:15601915

Putative homeodomain transcription factor 1 interacts with the feminization factor homolog fem1b in male germ cells.

PMID:36803935

Structural screens identify candidate human homologs of insect chemoreceptors and cryptic Drosophila gustatory receptor-like proteins.