Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
The heterologous siderophores ferrioxamine B and ferrichrome activate signaling pathways in Pseudomonas aeruginosa.
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FoxA is produced only in the presence of ferrioxamine B, and its induction depends on the adjacent foxI-foxR locus.
"Two of them are only produced in the presence of the hydroxamate siderophores ferrioxamine B and ferrichrome"
The role of FoxA, FiuA, and FpvB in iron acquisition via hydroxamate-type siderophores in Pseudomonas aeruginosa.
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FoxA transports ferric nocardamine, bisucaberin, desferrioxamine B and desferrioxamine G.
"FoxA of the ferric forms of nocardamine, bisucaberin, DFOB and DFOG"
Transcription regulation of iron carrier transport genes by ECF sigma factors through signaling from the cell surface into the cytoplasm.
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Ferrioxamine B binding to FoxA triggers transcription of ferrioxamine transport genes.
"The binding of Fe3+ferrioxamine B to the FoxA OM protein triggers the transcription of ferrioxamine transport genes"
Self-cleavage of the Pseudomonas aeruginosa Cell-surface Signaling Anti-sigma Factor FoxR Occurs through an N-O Acyl Rearrangement.
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Ferrioxamine binding to FoxA leads to FoxR processing and FoxI activation.
"Upon binding of ferrioxamine by the FoxA receptor, FoxR is processed by a complex proteolytic cascade leading to the release and activation of σ(FoxI)"
UniProt entry Q9I116 (Q9I116_PSEAE)