Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Combined Automated Annotation using Multiple IEA Methods
Identification of Cox20p, a novel protein involved in the maturation and assembly of cytochrome oxidase subunit 2.
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Cox20 is a mitochondrial inner membrane Cox2 chaperone required for Cox2 maturation and cytochrome oxidase assembly.
"Cox20p specifically binds the newly synthesized pCox2p, a step required to present the exported pCox2p as a substrate to the Imp1p peptidase."
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics.
Quantitative variations of the mitochondrial proteome and phosphoproteome during fermentative and respiratory growth in Saccharomyces cerevisiae.
A Role for COX20 in Tolerance to Oxidative Stress and Programmed Cell Death in Saccharomyces cerevisiae.
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COX20 expression reduces oxidative-stress-associated apoptotic and necrotic cell populations, but the study frames this around the known Cox2 chaperone role.
"Overexpression of COX20 reduced the presence of apoptotic cells in assays with hydrogen peroxide, cobalt, copper, manganese iron and cadmium"
Falcon deep research report on COX20
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Falcon synthesis identifies Cox20 as a Cox2-specific inner-membrane chaperone that coordinates Cox2 processing, C-tail export, and stability.
"COX20 encodes an integral mitochondrial inner-membrane Cox2-specific chaperone/assembly factor required for productive cytochrome c oxidase (Complex IV) biogenesis."
PANTHER family PTHR31586 metadata