Authentic cadherin domain mappings support the imported calcium, adhesion and membrane assertions; target evidence supplies narrower refinements.

Literal mouse O55111 donor records were joined to the source terms, with actual source/organism limits retained.

Current target lineage, three literal IBD terms and exact 1118-residue MSA target were reconstructed; target self-inclusion is legitimate descendant grounding.

Curated location mappings accommodate distinct intact, intracellular-fragment and shed extracellular pools.

Target HPA observations have individual location ratings: cell junctions and plasma membrane supported, vesicles approved.

Imported ortholog transfers are retained with exact donor identity and context-specific experimental grounding.

Current ARBA00028309 target conditions match; the current ARBA00028427 nonmatch does not prove the historical junction mapping invalid.

Combined domain, curated-location and ortholog evidence are distinguished rather than treated as one direct experiment.

Full-length human PKP2a associates with expressed human DSG2 in COS-cell co-immunoprecipitation; PKP2 head and full-length constructs differ in two-hybrid/native-capture outcomes.

Human DSG2 variants are associated with ARVC and biopsy desmosomal remodeling, including reduced desmosome number and widened gaps in three examined carriers.

Staurosporine-induced apoptosis in HaCaT and HT-29 cells causes caspase-dependent DSG2 cleavage, release of a 70-kDa cytosolic fragment, plakoglobin detachment and weakened intercellular adhesion.

Human parotid-saliva exosome proteomics identifies DSG2: Supplementary Table 2 lists two sequences, two spectra and sequence coverage 0.044 for IPI00028931.2/DSG2.

HeLa cell-surface glycoproteins were profiled by surface capture, SILAC and mass spectrometry.

DSG2 localizes to cell borders in human HaCaT and HCT116 controls and loses border staining after PKP3 depletion.

The study includes a human DSG2–DSC2 affinity record and cardiac localization of expressed cadherin constructs.

Human wild-type and mutant DSG2 proteins are detected in patient-derived material and incorporated into desmosomes.

Human epithelial/cancer-cell assays connect DSG2 with EGFR, c-Src and caveolin redistribution and signalling.

Human desmoglein and desmocollin ectodomains form adhesive heterophilic interactions, including DSG2–DSC2.

Human progenitor/endothelial cells show non-desmosomal DSG2 surface and cytoplasmic pools; knockdown affects tube formation, elongation and junction-associated actin.

Human DSG2 extracellular fragments bind adenovirus type 3 fiber knob, with a defined EC2/EC3 contribution and measured stoichiometry.

Human pluripotent-cell and fibroblast experiments link DSG2 to cell-state maintenance, beta-catenin association and epithelial/mesenchymal transitions.

Human keratinocyte imaging places DSG2 in nascent desmosomes; AFM shows DSG2–DSC2 heterophilic binding, while DSG2 homophilic events are at background in this assay.

Cryo-EM resolves human DSG2 engagement by adenovirus type 3 fiber knob.

Wild-type and disease-associated DSG2 variants show different glycosylation patterns in biochemical analyses.

DSG2 is a DHHC5 substrate, and the DHHC5/Golga7b system is required for its plasma-membrane localization and desmosomal patterning.

Human DSG2 propeptide-cleavage-site variants alter extracellular interactions and stress-dependent desmosomal incorporation/internalization without necessarily preventing junction targeting.

Human SKCO-15 intestinal epithelial assays show DSG2 recruitment during calcium-induced junction assembly and load on an engineered DSG2 FRET sensor.

H. pylori HtrA cleaves DSG2 extracellular material in human gastric epithelial and recombinant-fragment assays.

The human receptor network includes the DSG2–DSC2 interaction with a 29000-nM affinity imported from PMID:27298358.

Human pancreatic specimens/cell observations show DSG2 localization; mouse hypomorph and beta-cell experiments establish separate islet, insulin and vascular phenotypes.

A human S194L case shows altered DSG2/connexin43 expression and distribution, including perinuclear accumulation and abnormal intercalated-disc morphology.

Human HK-2 DSG2 depletion weakens cell-cell adhesion and increases death, while injured mouse tubular-epithelial knockouts show increased apoptosis and inflammation.

The study characterizes human/bovine DSG2 in the examined desmosome-containing tissues and cells.

An exact participant/component path (351877 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

An exact participant/component path (6809393 → 6814388 → 6814694 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

An exact participant/component path (6810357 → 8942225 → 6814735 → 6814388 → 6814694 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

An exact participant/component path (6810937 → 6814285 → 6814323 → 8942225 → 6814735 → 6814388 → 6814694 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

An exact participant/component path (6811539 → 6814323 → 8942225 → 6814735 → 6814388 → 6814694 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

An exact participant/component path (6814298 → 6814723 → 6814278 → 6814285 → 6814323 → 8942225 → 6814735 → 6814388 → 6814694 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

An exact participant/component path (6814387 → 6814275 → 6814723 → 6814278 → 6814285 → 6814323 → 8942225 → 6814735 → 6814388 → 6814694 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

An exact participant/component path (6814695 → 6814388 → 6814694 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

An exact participant/component path (6814734 → 6814278 → 6814285 → 6814323 → 8942225 → 6814735 → 6814388 → 6814694 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

An exact participant/component path (6814764 → 6814763 → 6814757 → 6814758 → 6814759 → 6814760 → 6814735 → 6814388 → 6814694 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

An exact participant/component path (8942224 → 6814735 → 6814388 → 6814694 → 351896) reaches human Q14126 residues 50–1118 at the plasma membrane. This is component or substrate participation in the event, not a DSG2 enzyme assignment.

Mouse Dsg2 loss impairs embryonic stem-cell proliferation and early development, with non-desmosomal junctional localization.

The citation supplies a curated mouse PKP2 cellular-component assertion used in the partner-class provenance chain.

Mouse Dsg2 N271S transgenes cause cardiomyopathy and conduction abnormalities despite preserved morphologically normal desmosomes in the examined hearts.

Human DSG2 binds adenovirus type 3 and supports attachment/transduction; gain in receptor-negative human cells and inhibitory/depletion assays establish receptor function.

Human DSG2 homophilic AFM interactions and disease-associated construct effects support an adhesive role in defined assay contexts.

Mouse cardiomyocyte-specific Dsg2 depletion reduces desmosome-like structures and causes postnatal conduction disease.

Wild-type DSG2 extracellular-domain–Fc constructs show homotypic AFM binding that is reduced by W2A, alongside human CaCo2 and mouse adhesion experiments.

HPA004896 records A-431 junction/vesicle observations and KOLF2.1J plasma-membrane/junction observations; CAB025122 supports A-431 junctions. Individual HTML ratings distinguish approved vesicles from supported membrane/junctions.