Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods
Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase.
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Purified P. aeruginosa FabV reduces enoyl-ACP with NADH and confers triclosan resistance.
"The addition of PaFabV, PaFabI, or EcFabI plus NADH to the reaction mixture yielded butyryl-ACP"
Functional Characterization of Triclosan-Resistant Enoyl-acyl-carrier Protein Reductase (FabV) in Pseudomonas aeruginosa.
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Enoyl-ACP reductase activity in extracts of the fabV deletion strain is about 37% of wild type; deletion also lowers AHL production, swarming and virulence factors.
"The ENR activity (in μmol/min per mg extract protein) in cell-free extract of PAO170 was 0.175 ± 0.006, and was lower than that in the cell-free extract of wild-type strain PAO1 (0.478 ± 0.032)."
UniProt entry Q9HZP8 (FABV_PSEAE)