Deep research report on FGFR3 (falcon)
UniProtKB/Swiss-Prot entry P22607 (FGFR3_HUMAN)
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4.
Identification of tyrosine residues in constitutively activated fibroblast growth factor receptor 3 involved in mitogenesis, Stat activation, and phosphatidylinositol 3-kinase activation.
Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity.
Cell responses to FGFR3 signalling: growth, differentiation and apoptosis.
A human protein-protein interaction network: a resource for annotating the proteome.
Sustained phosphorylation of mutated FGFR3 is a crucial feature of genetic dwarfism and induces apoptosis in the ATDC5 chondrogenic cell line via PLCgamma-activated STAT1.
The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion.
Generation of Fgfr3 conditional knockout mice.
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.
Structural mimicry of a-loop tyrosine phosphorylation by a pathogenic FGF receptor 3 mutation.
Structure of FGFR3 transmembrane domain dimer: implications for signaling and human pathologies.
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
A Human IgSF Cell-Surface Interactome Reveals a Complex Network of Protein-Protein Interactions.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Physical and functional interactome atlas of human receptor tyrosine kinases.
Fibroblast growth factor receptor 3 is a negative regulator of bone growth.
Receptor specificity of the fibroblast growth factor family.
PI3K-containing complexes phosphorylate PIP2 to PIP3
Autocatalytic phosphorylation of FGFR3b
Autocatalytic phosphorylation of FGFR3c
Autocatalytic phosphorylation of FGFR3c P250R mutant
FGFR3c P250R mutant binds to ligand with enhanced affinity
Autocatalytic phosphorylation of FGFR3 cysteine mutants
Constitutive dimerization of FGFR3 cysteine mutants
Dimerization of FGFR3 point mutants with enhanced kinase activity
Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity
Dimerization of FGFR3 t(4;14) translocation mutants
Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
p-4Y-PLCG1 dissociates from activated FGFR3
Activated FGFR3 phosphorylates PLCG1
Activated FGFR3 binds PLCG1
Activated FGFR3 phosphorylates FRS2
Activated FGFR3 binds FRS2
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3:pFRS binds GRB2:SOS1
Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2
Activated FGFR3 binds FRS3
Activated FGFR3 binds SHC1
Activated FGFR3 phosphorylates FRS3
Activated FGFR3 phosphorylates PPTN11
Activated FGFR3:p-FRS bind to PPTN11
Activated FGFR3 phosphorylates SHC1
Activated FGFR3:p-FRS2 binds GRB2:GAB1:PIK3R1
Activated FGFR3:p-FRS2:GRB2:GAB1:PI3KR1 binds PIK3CA
Activated FGFR3:p-FRS2:p-PPTN11 binds GRB2:GAB1:PI3KR1
Activated FGFR3:p-FRS2:p-PPTN11:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3:p-SHC1 binds GRB2:SOS1
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
CBL ubiquitinates FRS2 and FGFR3
FGFR3-associated PI3K phosphorylates PIP2 to PIP3
FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3
p-CBL:GRB2 binds p-FRS2:activated FGFR3
Activated FGFR3 point and translocation mutants phosphorylate PLCG1
Activated FGFR3 point and translocation mutants bind PLCG1
p-4Y-PLCG1 dissociates from activated FGFR3 point and translocation mutants
Activated FGFR3 point, translocation and fusion mutants bind FRS2
Activated FGFR3 point, translocation and fusion mutants phosphorylate FRS2
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange
Activated FGFR3 point, translocation and fusion mutants:p-FRS2:GRB2:GAB1:PIK3R1 binds PIK3CA
Activated FGFR3 point, translocation and fusion mutant-associated PI3K phosphorylates PIP2 to PIP3
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2-SOS1
Activated FGFR3 point, translocation and fusion mutants:p-FRS2 binds GRB2:GAB1:PIK3R1
RAS GEFs promote RAS nucleotide exchange
Autocatalytic phosphorylation of FGFR3 fusions