GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10766744
Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and -5 markedly reduce IGF-I binding and alter their biologic actions.
PMID:11940579
Insulin-like growth factor-binding protein-3 activates a phosphotyrosine phosphatase. Effects on the insulin-like growth factor signaling pathway.
PMID:11971816
Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation.
PMID:12599210
Role of insulin-like growth factor binding protein-3 (IGFBP-3) in the differentiation of primary human adult skeletal myoblasts.
PMID:14561895
Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis.
PMID:14576163
Insulin-like growth factor-independent effects mediated by a C-terminal metal-binding domain of insulin-like growth factor binding protein-3.
PMID:14718574
The human plasma proteome: a nonredundant list developed by combination of four separate sources.
PMID:17119061
Ethnic disparity in the relationship between obesity and plasma insulin-like growth factors: the multiethnic cohort.
PMID:17434920
Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3.
PMID:17591901
The requirement of pax6 for postnatal eye development: evidence from experimental mouse chimeras.
PMID:19258508
NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation.
PMID:20353938
Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer.
PMID:23178489
The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents.
PMID:26216267
Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3) and Regulates Its Interaction with Importin-β.
PMID:30184438
Interaction of Insulin-Like Growth Factor-Binding Protein 3 With Hyaluronan and Its Regulation by Humanin and CD44.
PMID:32814053
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
PMID:9388210
Inhibition of insulin receptor activation by insulin-like growth factor binding proteins.
PMID:9497324
Insulin-like growth factor (IGF)-binding protein 5 forms an alternative ternary complex with IGFs and the acid-labile subunit.
Reactome:R-HSA-381435
Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS
Reactome:R-HSA-381446
Thrombin proteolyzes IGF:IGFBP3:ALS
Reactome:R-HSA-381461
Plasmin proteolyzes IGF:IGFBP-3:ALS
Reactome:R-HSA-381466
Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS
Reactome:R-HSA-381496
Formation of the IGF:IGFBP3:ALS complex
Reactome:R-HSA-381500
Cathepsin G proteolyzes IGF:IGFBP3:ALS
Reactome:R-HSA-6800035
IGFBP3 binds TMEM219
Reactome:R-HSA-6800044
TP53 stimulates IGFBP3 expression
Reactome:R-HSA-8952289
FAM20C phosphorylates FAM20C substrates
file:human/IGFBP3/IGFBP3-deep-research-falcon.md
Falcon deep research synthesis for IGFBP3
file:human/IGFBP3/IGFBP3-uniprot.txt
UniProt record for IGFBP3