Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.
Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
Structural and biochemical basis of apoptotic activation by Smac/DIABLO.
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP).
Comparative gene identification-94--a pivotal regulator of apoptosis.
Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein.
Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.
Solution structure of human survivin and its binding interface with Smac/Diablo.
Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases.
Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway.
No death without life: vital functions of apoptotic effectors.
The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.
ARTS and Siah collaborate in a pathway for XIAP degradation.
Survivin monomer plays an essential role in apoptosis regulation.
ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists.
Identification of a novel protein kinase Cδ-Smac complex that dissociates during paclitaxel-induced cell death.
Impairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex.
Identification of a novel anti-apoptotic E3 ubiquitin ligase that ubiquitinates antagonists of inhibitor of apoptosis proteins SMAC, HtrA2, and ARTS.
A proteome-scale map of the human interactome network.
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosis.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases.
Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
Structural basis for SMAC-mediated antagonism of caspase inhibition by the giant ubiquitin ligase BIRC6.
Multimodal cell maps as a foundation for structural and functional genomics.
Release of SMAC (DIABLO) from mitochondria
SMAC binds XIAP:Caspase-7
Dissociation of Caspase-7 from DIABLO:XIAP:Caspase-7
SMAC (DIABLO) forms dimer
Role of Smac/DIABLO in hydrogen peroxide-induced apoptosis in C2C12 myogenic cells.
Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis.
HOIL-1L interacting protein (HOIP) as an NF-kappaB regulating component of the CD40 signaling complex.
Role of Smac in human leukaemic cell apoptosis and proliferation.
Requirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by Smac.