Q9VQD1 is the 395-residue PA product of FBgn0031431 (AAF51244/NP_608687), with one protein-coding transcript. Its record contains DR InterPro; IPR037867; Swd2/WDR82.; the family assignment is more diagnostic than generic WD40 repeats. FlyBase.
CG3515 is not Wdr82/CG17293 (FBgn0032030, Q9VLN1). The current FlyBase orthology table nevertheless places CG3515 with human WDR82 (7/14 DIOPT methods, best target score but not best reverse score). This is consistent with a diverged paralog and with the curated PAINT chromatin/COMPASS assignment. A paralog distinction warrants keeping direct experimental attribution accurate; it does not alone demonstrate loss of conserved nuclear localization.
PMID:18838538(https://pubmed.ncbi.nlm.nih.gov/18838538/) establishes that human WDR82 associates with chromatin and Set1 complexes. The cached abstract directly supports that family property; full-text fetching encountered a publisher/browser restriction. The accessible primary search excerpt identifies CG17293 as the closest fly sequence, and is not represented as evidence that CG3515 itself was assayed. Nuclear localization and chromatin/COMPASS roles are accepted as conserved-family inferences. A specific CG3515 RNA-metabolic role remains unresolved; no histone methyltransferase activity is assigned to the WD-repeat subunit itself.
ProtNLM nucleus is CNN: this broad location is supported by nuclear-complex family biology and already occurs in the record. The original location score and donor metadata remain in the frozen prediction JSON.
Research-provider outcome: the default Falcon process timed out after 600 seconds. The configured perplexity-lite fallback returned HTTP 401 (insufficient_quota). The original Falcon child subsequently produced a complete report (614.92 seconds), which was inspected. Its CG3515/CG17293 distinction agrees with the identity analysis. It identified the primary comparative Swd2 analysis PMID:15146080(https://doi.org/10.1261/rna.7090104), now cached as an abstract; the report's exact CG3515 alignment row has not been independently recovered from full text. The primary yeast study establishes dual chromatin and RNA-processing roles, while the present fly review treats chromatin/COMPASS as conserved-family inference and leaves specific RNA processing unresolved. The provider's absence of a direct fly assay does not itself refute the curated phylogenetic inference.