GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000044
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
PMID:21693646
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signaling.
PMID:21727895
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling.
PMID:22815884
R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.
PMID:23439653
Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network.
PMID:23809763
Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5.
PMID:29769720
RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.
PMID:9642114
Identification and cloning of an orphan G protein-coupled receptor of the glycoprotein hormone receptor subfamily.
Reactome:R-HSA-4641205
RSPO:LGR binds ZNRF3
Reactome:R-HSA-4641206
RSPOs bind LGRs
Reactome:R-HSA-4641246
ZNRF3 autoubiquitinates to promote its internalization
file:human/LGR5/LGR5-uniprot.txt
UniProt record O75473 (LGR5)