Gene Ontology annotation through association of InterPro records with GO terms
TreeGrafter-generated GO annotations
UniProtKB entry for PP_3117/ImuA (Q88I84)
Widespread distribution of a lexA-regulated DNA damage-inducible multiple gene cassette in the Proteobacteria phylum.
Inhibition of FtsZ polymerization by SulA, an inhibitor of septation in Escherichia coli.
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Canonical SulA inhibits division through FtsZ polymerization. This comparator defines the legacy functional mapping; it does not assay Q88I84 or establish absence of every division-related effect in ImuA proteins.
"These results indicate that SulA blocks Z ring formation by blocking FtsZ polymerization."
Study of involvement of ImuB and DnaE2 in stationary-phase mutagenesis in Pseudomonas putida.
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In P. putida, DnaE2 acts as an anti-mutator for stationary-phase base substitutions, so the cassette's mutational output in this organism is condition-dependent rather than uniformly error-prone.
"it acted as an anti-mutator in accumulation of base substitution"
An SOS-regulated operon involved in damage-inducible mutagenesis in Caulobacter crescentus.
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Ortholog genetics establishes ImuA as part of a required damage-inducible mutagenesis unit.
"all three genes that compose this expression unit are involved"
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Caulobacter imuA/imuB genetics support damage tolerance in that organism; this is ortholog evidence, not a purified PSEPK assay.
"The genes imuA and imuB encode previously uncharacterized proteins, which are shown here for the first time to be involved in DNA damage tolerance."
DNA Polymerases ImuC and DinB Are Involved in DNA Alkylation Damage Tolerance in Pseudomonas aeruginosa and Pseudomonas putida.
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The native experiments use PaW85 derivatives, described as isogenic to the KT2440 reference strain.
"All Pseudomonas putida strains are derivatives of PaW85 [54], which is isogenic to KT2440 [55]."
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Individual imuA, imuB and imuC deletions compromise alkyl-damage tolerance in an AlkA-deficient background; ImuB complementation addresses polarity.
"ImuB and ImuA are both required for the involvement of ImuC in the DNA alkyl damage tolerance in pseudomonads."
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ImuC promotes MMS-induced mutagenesis in the tested conditions, despite older antimutator results under different stresses.
"indicating that ImuC is responsible for the MMS mutability in P. putida"
Myxococcus xanthus translesion DNA synthesis protein ImuA is an ATPase enhanced by DNA.
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Myxococcus ImuA exhibits DNA-enhanced ATPase activity and direct ImuB interaction; this is a biochemical comparator, not a measurement of PSEPK Q88I84.
"Here we show that M. xanthus ImuA, like RecA, hydrolyzes ATP."