An antibiotic factory caught in action.
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CLF regulates polyketide chain length but has no active site; the KS subunit is the catalytic one.
"Although CLF regulates chain length, it does not have an active site; KS must catalyze both chain initiation and elongation."
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KS and CLF form a heterodimer; the polyketide is elongated in a tunnel at the heterodimer interface.
"the actinorhodin KS-CLF, which shows polyketides being elongated inside an amphipathic tunnel approximately 17 A in length at the heterodimer interface"
actI-ORF2 review notes (BGC project) with predicted-complex evidence
Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Ensembl/EnsemblGenomes orthology