VIN3 curation notes

Session 2026-10-05 (vernalization_flc_silencing module)

• Q9FIE3, At5g57380. Falcon deep research failed (agentapi missing / timeout).
• Founding paper: PMID:14712276
• PHD-PRC2: PMID:18854416 plus VRN5, VIN3, VEL1.
• Heterodimer with VRN5: PMID:17174094.
• Not an H3 reader: PMID:36174674 An earlier pull-down claimed H3 binding (cited within that paper); the quantitative assays supersede it. IBA histone H3 reader activity was therefore REMOVED.
• VEL polymerization: PMID:36351412; in vivo: PMID:40858112. Basis for the NEW GO:0140693 molecular condensate scaffold activity.
• VRN5 bridges VIN3 to PRC2: PMID:40858112.
• Nucleation vs spreading: PMID:28818969.
• Hypoxia (secondary): PMID:19392705.

Decisions

• IBA constitutive heterochromatin formation -> MODIFY to facultative heterochromatin formation (GO:0140718), since this is Polycomb silencing.
• Protein binding: VIL1/VEL1 rows -> MODIFY to protein heterodimerization activity; VRN2 and 14-3-3 rows -> REMOVE.