Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
The fibronectin-binding MSCRAMM FnbpA of Staphylococcus aureus is a bifunctional protein that also binds to fibrinogen.
Fibrinogen interactions with ICAM-1 (CD54) regulate endothelial cell survival.
Afibrinogenemia: first identification of a splicing mutation in the fibrinogen gamma chain gene leading to a major gamma chain truncation.
Fibrinogen Magdeburg I: a novel variant of human fibrinogen with an amino acid exchange in the fibrinopeptide A (Aalpha 9, Leu-->Pro).
Fibrinogen and fragment D-induced vascular constriction.
Human colostrum: identification of minor proteins in the aqueous phase by proteomics.
The fibrinogen Aalpha R16C mutation results in fibrinolytic resistance.
Congenital hypofibrinogenemia: characterization of two missense mutations affecting fibrinogen assembly and secretion.
Large-scale proteomics and phosphoproteomics of urinary exosomes.
Fibrinogen-induced endothelin-1 production from endothelial cells.
Crystal structure of human fibrinogen.
Role of Mycoplasma pneumoniae glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in mediating interactions with the human extracellular matrix.
Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.
In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
The role of fibrin matrices and tissue factor in early-term trophoblast proliferation and spreading.
Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.
Extracellular Fibrinogen-binding Protein (Efb) from Staphylococcus aureus Inhibits the Formation of Platelet-Leukocyte Complexes.
Comprehensive proteomic characterization of stem cell-derived extracellular matrices.
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
MatrisomeDB 2.0: 2023 updates to the ECM-protein knowledge database.
gamma and alpha chains of human fibrinogen possess sites reactive with human platelet receptors.
Localization of a fibrin polymerization site.
Ca2+-mediated association of glycoprotein G (thrombinsensitive protein, thrombospondin) with human platelets.
Structural recognition of a novel fibrinogen gamma chain sequence (117-133) by intercellular adhesion molecule-1 mediates leukocyte-endothelium interaction.
Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway.
Paris I dysfibrinogenemia: a point mutation in intron 8 results in insertion of a 15 amino acid sequence in the fibrinogen gamma-chain.
The role of betagamma and alphagamma complexes in the assembly of human fibrinogen.
Crystal structure of fragment double-D from human fibrin with two different bound ligands.
Adhesion of integrin αIIbβ3 to fibrin network
fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B
n fibrin monomers -> fibrin multimer
fibrin multimer -> fibrin multimer, crosslinked + NH4+
MyD88 forms a complex with TIRAP:activated TLR2/4
IRAK4 binds to the activated TLR receptor:TIRAP:MyD88 complex
IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:TIRAP complex
First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal
Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP
Multiple IRAK1 autophosphorylation steps
Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
Interaction of integrin alphaDbeta2 with fibrin
Interaction of integrin alphaXbeta2 with fibrin
Activated TLR2/4 interacts with MAL (TIRAP)
TIRAP is phosphorylated by BTK
Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:TIRAP:p-IRAK4 complex
Activated TLR2/4:TIRAP interacts with BTK
Translocation of PTK2 to Focal complexes
Autophosphorylation of PTK2 at Y397
Recruitment of GRB2 to p-PTK2
Phosphorylation of pPTK2 by SRC
Interaction of integrin alphaIIb beta3 with Fibrinogen
Interaction of SOS with GRB2 bound to FADK1
Phosphorylation of BCAR1 by SRC-PTK2 complex
Recruitment of BCAR1 to PTK2 complex
Autophosphorylation of SRC
Clustering of Integrin alphaIIb beta3 complexes
Dephosphorylation of inactive SRC by PTPB1
SYK binds to integrin alphaIIb beta3
Exocytosis of platelet alpha granule contents
Defective IRAK4 does not bind MyD88:MAL:BTK:activated TLR2/4
Defective MyD88 does not oligomerize within the activated TLR2/4 complex
Defective MyD88 does not bind MAL(TIRAP):TLR2/4
Cleaved fibrinogen products bind TLR4:LY96
FAM20C phosphorylates FAM20C substrates
IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP
Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex
MyD88 oligomerization within the complex of activated TLR:TIRAP:MyD88
αIIbβ3:fibrin multimer ->αIIbβ3:fibrin multimer, crosslinked + NH4+
fibrinogen + β-amyloid fibril:Zn2+ -> fibrinogen:β-amyloid fibril:Zn2+
The primary fibrin polymerization pocket: three-dimensional structure of a 30-kDa C-terminal gamma chain fragment complexed with the peptide Gly-Pro-Arg-Pro.
FGG source joins, phylogeny, products and rule provenance
UniProtKB P02679 fibrinogen gamma chain