MVD1 / ERG19 (YNR043W) notes

UniProt P32377; diphosphomevalonate decarboxylase, EC 4.1.1.33; homodimer [UniProt:P32377].

Evidence journal

• Cloned/expressed: PMID:8626466
• Active site: PMID:15169949; K18M raises Km(ATP).
• Mutants: PMID:1779710
• Essential, overexpression lowers sterols PMID:9244250.

Decisions

• Vacuole NAS (Hu et al. 2017 review) REMOVE. Carboxy-lyase IEA MODIFY -> GO:0004163. Rest ACCEPT.