Protein degradation in signaling.
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The cited review discusses plant ubiquitin/proteasome signaling broadly; source-specific COI1 detail is not exposed in the abstract.
"Recent studies have linked proteolysis by the ubiquitin/proteasome pathway to a variety of signaling pathways in higher plants."
Genes controlling expression of defense responses in Arabidopsis--2001 status.
The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis.
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COI1 is a component of SCF(COI1) E3 ubiquitin ligase complexes.
"In this study, we demonstrate that COI1 associates physically with AtCUL1, AtRbx1, and either of the Arabidopsis Skp1-like proteins ASK1 or ASK2 to assemble ubiquitin-ligase complexes, which we have designated SCF(COI1)."
Major signaling pathways modulate Arabidopsis glucosinolate accumulation and response to both phloem-feeding and chewing insects.
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coi1 has reduced constitutive glucosinolate concentrations; lack of an effect on induced accumulation does not describe all insect-performance endpoints.
"Blocked JA signaling in coronatine-insensitive (coi1) and enhanced expression of SA-signaled disease resistance in hypersensitive response-like (hrl1) mutants reduced constitutive GS concentrations,"
Expression profiling reveals COI1 to be a key regulator of genes involved in wound- and methyl jasmonate-induced secondary metabolism, defence, and hormone interactions.
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COI1 is required for jasmonate-responsive gene expression.
"We show that COI1 is required for expression of approximately 84% of 212 genes induced by JA, and for expression of approximately 44% of 153 genes induced by wounding."
Conserved requirement for a plant host cell protein in powdery mildew pathogenesis.
Plant stomata function in innate immunity against bacterial invasion.
ABA is an essential signal for plant resistance to pathogens affecting JA biosynthesis and the activation of defenses in Arabidopsis.
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The pathogen studied is the oomycete Pythium irregulare; this establishes the taxonomic correction for the defense annotation.
"Analyses of Arabidopsis thaliana defense response to the damping-off oomycete pathogen Pythium irregulare show that resistance to P. irregulare requires a multicomponent defense strategy."
The JAZ family of repressors is the missing link in jasmonate signalling.
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COI1 directs JAZ repressors into SCF-dependent proteasomal degradation.
"Our results demonstrate that JAI3 and other JAZs are direct targets of the SCF(COI1) E3 ubiquitin ligase and jasmonate treatment induces their proteasome degradation."
JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling.
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JA-Ile promotes COI1-JAZ1 interaction and SCF(COI1)-dependent JAZ1 degradation, initiating jasmonate signaling.
"Jasmonate treatment causes JAZ1 degradation and this degradation is dependent on activities of the SCF(COI1) ubiquitin ligase and the 26S proteasome."
Jasmonate and phytochrome A signaling in Arabidopsis wound and shade responses are integrated through JAZ1 stability.
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COI1 is required for far-red-induced transcription and participates in phyA/jasmonate crosstalk.
"Additionally, we demonstrate that the FR light-induced expression of transcription factor genes is dependent on CORONATINE INSENSITIVE1 (COI1), a central component of JA signaling, and is suppressed by JA."
Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor.
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COI1 is the F-box substrate-recognition/adaptor subunit of SCF(COI1), recruiting JAZ repressors in the jasmonate co-receptor complex.
"The F-box protein CORONATINE INSENSITIVE 1 (COI1) mediates jasmonate signalling by promoting hormone-dependent ubiquitylation and degradation of transcriptional repressor JAZ proteins."
New clothes for the jasmonic acid receptor COI1: delayed abscission, meristem arrest and apical dominance.
Endogenous Bioactive Jasmonate Is Composed of a Set of (+)-7-iso-JA-Amino Acid Conjugates.
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Additional endogenous bioactive jasmonate amino-acid conjugates were identified; COI1 mediates ligand-dependent JAZ degradation.
"Here, we designed coronafacic acid (CFA) conjugates with all the amino acids (CFA-AA) to mimic the JA amino acid conjugates, and revealed that (+)-7-iso-JA-Leu, (+)-7-iso-JA-Val, (+)-7-iso-JA-Met, and (+)-7-iso-JA-Ala are new endogenous bioactive JA molecules."
Extracellular ATP Shapes a Defense-Related Transcriptome Both Independently and along with Other Defense Signaling Pathways.
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COI1 is implicated in extracellular ATP-associated defense transcriptome responses.
"In conclusion, we present a model ( Fig. 10 ) in which ATP binding to P2K1 results in defense gene activation, where more than half of ATP-responsive genes required signaling by one or more of the pathways through EIN2, NPR1, and COI1, but with a more substantial reliance on COI1."
COI1: an Arabidopsis gene required for jasmonate-regulated defense and fertility.
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COI1 is required for jasmonate-regulated defense responses.
"The coi1 mutation defines an Arabidopsis gene required for response to jasmonates, which regulate defense against insects and pathogens, wound healing, and pollen fertility."
UniProt record for Arabidopsis COI1
Falcon deep research report for Arabidopsis COI1
The jasmonoyl-isoleucine receptor CORONATINE INSENSITIVE1 suppresses defense gene expression in Arabidopsis roots independently of its ligand.
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A COI1 variant impaired in JAZ interaction retains repression of a JA-Ile-independent root gene set, suggesting a separable regulatory function.
"On the other hand, genes affected by COI1 but not by JA-Ile were still strongly repressed by COI1AA ."
CORONATINE INSENSITIVE 1-mediated repression of immunity-related genes in Arabidopsis roots is lifted upon infection with Verticillium longisporum.
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COI1 represses a root immunity-related gene set independently of JA-Ile synthesis.
"The biggest difference between the transcriptomes was due to 316 immunity-related genes that were constitutively higher expressed in coi1 as compared to the susceptible genotypes."
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Disrupting a subgroup of the derepressed genes partially suppresses the coi1 tolerance phenotype, linking expression regulation to defense.
"Interfering with the expression of a sub-group of these genes partially suppressed the coi1-mediated tolerance phenotype."
OpenScientist hypothesis report on COI1 JA-independent root repression