Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by ARBA machine learning models
Drosophila dSmad2 and Atr-I transmit activin/TGFbeta signals.
Genetics of heart development.
The zinc finger protein schnurri acts as a Smad partner in mediating the transcriptional response to decapentaplegic.
Transgenic analysis of the Smad family of TGF-beta signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members.
Organ formation in Drosophila: specification and morphogenesis of the salivary gland.
Control of cardiac development by an evolutionarily conserved transcriptional network.
Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient.
-
Medea participates in repression of Pol II-transcribed target genes.
"the brk silencer serves as a direct target for a protein complex consisting of the Smad homologs Mad/Medea and the zinc finger protein Schnurri."
Stepwise formation of a SMAD activity gradient during dorsal-ventral patterning of the Drosophila embryo.
Highwire regulates presynaptic BMP signaling essential for synaptic growth.
-
Highwire binding is real but bare protein binding is uninformative.
"Here we show that Hiw binds to the Smad protein Medea (Med)."
-
Medea-dependent presynaptic BMP signaling promotes NMJ assembly/growth.
"Med is part of a presynaptic bone morphogenetic protein (BMP) signaling cascade consisting of three receptor subunits, Wit, Tkv, and Sax, in addition to the Smad transcription factor Mad."
DPP signaling controls development of the lamina glia required for retinal axon targeting in the visual system of Drosophila.
-
Medea contributes to compound-eye development.
"gcm is reduced or absent in dpp mutants or Medea clones"
-
Medea-dependent transcription contributes to cell differentiation in several developmental settings.
"DPP signaling mediates the maturation of the lamina glia required for the correct R axon projection pattern by controlling the expression of gcm."
BMP signaling is required for controlling somatic stem cell self-renewal in the Drosophila ovary.
-
Medea-dependent BMP signaling regulates ovarian somatic stem-cell maintenance and follicle-lineage development.
"BMP signaling is required in SSCs to directly control their maintenance and division, but is dispensable for proliferation of their differentiated progeny."
Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons.
-
Medea participates in activin-associated neuronal development.
"We found that Baboon(Babo)/dSmad2-mediated TGF-beta signaling, known to be essential for remodeling of larval functional neurons, is also indispensable for proper morphogenesis of these adult-specific neurons."
Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism.
Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.
Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.
-
Medea enters and functions in the nucleus.
"Med is SUMO modified in the nucleus, and we provide evidence that SUMOylation triggers Med nuclear export."
A conserved activation element in BMP signaling during Drosophila development.
Fat facets deubiquitylation of Medea/Smad4 modulates interpretation of a Dpp morphogen gradient.
A genome-wide resource for the analysis of protein localisation in Drosophila.
Dichotomous cis-regulatory motifs mediate the maturation of the neuromuscular junction by retrograde BMP signaling.
-
Medea can activate transcription through BMP-responsive regulatory elements.
"both motifs mediate direct gene activation, with no involvement of the BMP derepression pathway regulators Schnurri and Brinker."
Drosophila Dpp and BMP signaling directly regulates dpp transcription for optimal ligand production.
Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.
Characterization of Medea, a gene required for maximal function of the Drosophila BMP homolog Decapentaplegic.
The Drosophila Medea gene is required downstream of dpp and encodes a functional homolog of human Smad4.
-
Medea is required for embryonic dorsal–ventral specification and patterning.
"Complete elimination of maternal and zygotic Medea activity in the early embryo results in a ventralized phenotype identical to that of null dpp mutants"
Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses.
-
Medea enters and functions in the nucleus.
"MEDEA is localized in the cytoplasm, is not regulated by phosphorylation, and requires physical association with MAD for nuclear translocation."
-
Medea contributes to imaginal-disc-derived wing morphogenesis.
"In the wing primordium, loss of Medea most severely affects regions receiving low DPP signal."
-
Medea is the shared co-Smad transcriptional effector of BMP signaling.
"MEDEA is most similar to mammalian Smad4 and forms heteromeric complexes with MAD."
The Drosophila gene Medea demonstrates the requirement for different classes of Smads in dpp signaling.
Interplay of signal mediators of decapentaplegic (Dpp): molecular characterization of mothers against dpp, Medea, and daughters against dpp.
Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm.
-
Medea binds cis-regulatory DNA as part of SMAD transcriptional complexes.
"Screens for binding factors yielded Tinman itself and the Smad4 homolog Medea."
-
Medea participates in the Dpp-dependent cardiac developmental program.
"induction of visceral mesoderm, dorsal muscles, and the heart by Dpp is, at least in part, effected through the transcriptional activation and function of the homeobox gene tinman"
decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary.
The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development.
-
Medea also transduces activin-family signals with Smox.
"Activated Babo associates with dSmad2 but not Mad, phosphorylates the carboxy-terminal SSXS motif and induces heteromeric complex formation with Medea, the Drosophila Smad4 homolog."