file:PSEPK/groES/groES-deep-research-falcon.md

Deep research report for groES (Q88N56 / PP_1360) in Pseudomonas putida KT2440

In KT2440, groES (PP_1360) lies immediately upstream of groEL (PP_1361) and both are induced together with rpoH under elevated pressure and aromatic-solvent stress, consistent with membership in the sigma-32/RpoH heat-shock regulon.

GO_REF:0000002

Gene Ontology annotation through association of InterPro records with GO terms

GO_REF:0000118

TreeGrafter-generated GO annotations

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:39169181

Visualizing chaperonin function in situ by cryo-electron tomography

GroEL/GroES forms folding chambers operating in the cytoplasm; both asymmetric (GroEL-GroES1) and symmetric (GroEL-GroES2) complexes are abundant and shift toward asymmetric under heat stress.

PMID:38064510

Structural basis of substrate progression through the bacterial chaperonin cycle

GroES binding to GroEL is ATP-dependent and approximately doubles chamber volume to create an encapsulated folding environment.