Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein.
Identification of the major phosphorylation site of the hepatitis C virus H strain NS5A protein as serine 2321.
The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR.
Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase.
Detection of a novel unglycosylated form of hepatitis C virus E2 envelope protein that is located in the cytosol and interacts with PKR.
The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain.
Protein synthesis and endoplasmic reticulum stress can be modulated by the hepatitis C virus envelope protein E2 through the eukaryotic initiation factor 2alpha kinase PERK.
Nucleophosmin interacts with and inhibits the catalytic function of eukaryotic initiation factor 2 kinase PKR.
Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.
TRAF family proteins link PKR with NF-kappa B activation.
Protein kinase R (PKR) interacts with and activates mitogen-activated protein kinase kinase 6 (MKK6) in response to double-stranded RNA stimulation.
Double-stranded RNA-dependent protein kinase is required for bone calcification in MC3T3-E1 cells in vitro.
Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases.
Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase.
Molecular basis for PKR activation by PACT or dsRNA.
Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon.
Antiviral action of the tumor suppressor ARF.
Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR.
The editing enzyme ADAR1 and the mRNA surveillance protein hUpf1 interact in the cell nucleus.
Nck-1 interacts with PKR and modulates its activation by dsRNA.
Protein kinase PKR mutants resistant to the poxvirus pseudosubstrate K3L protein.
PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control.
Double-stranded RNA-activated protein kinase inhibits hepatitis C virus replication but may be not essential in interferon treatment.
Defining the membrane proteome of NK cells.
New Cdc2 Tyr 4 phosphorylation by dsRNA-activated protein kinase triggers Cdc2 polyubiquitination and G2 arrest under genotoxic stresses.
Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.
Multiple forms of PKR present in the nuclei of acute leukemia cells represent an active kinase that is responsive to stress.
Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense.
Raftlin is involved in the nucleocapture complex to induce poly(I:C)-mediated TLR3 activation.
Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.
The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G₁ arrest.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Novel role of PKR in inflammasome activation and HMGB1 release.
Protein kinase PKR amplification of interferon β induction occurs through initiation factor eIF-2α-mediated translational control.
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.
p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.
Moco biosynthesis and the ATAC acetyltransferase engage translation initiation by inhibiting latent PKR activity.
A reference map of the human binary protein interactome.
Chikungunya virus infection induces differential inflammatory and antiviral responses in human monocytes and monocyte-derived macrophages.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
SARS-CoV-2 nucleocapsid protein impairs stress granule formation to promote viral replication.
Interactome Analysis of the Nucleocapsid Protein of SARS-CoV-2 Virus.
SARS-CoV-2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
A proteome-scale map of the SARS-CoV-2-human contactome.
The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity.
Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein.
Homologous regions of the alpha subunit of eukaryotic translational initiation factor 2 (eIF2alpha) and the vaccinia virus K3L gene product interact with the same domain within the dsRNA-activated protein kinase (PKR).
Expression of IFN-induced genes
ISGylation of host proteins
Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18
p-PKR dimer localizes to the nucleus
PKR binds activating host RNA
PKR dimer autophosphorylates
FA core complex:HSP70s binds PKR
p-PKR dimer phosphorylates eIF2-alpha
HCMV TRS1 binds PKR dimer
p-PKR dimer phosphorylates DHX9
p-PKR dimer phosphorylates CDK1
p-PKR dimer phosphorylates MKK6
p-PKR dimer phosphorylates TP53 tetramer
p-PKR dimer phosphorylates ILF3:ILF2
p-PKR dimer phosphorylates MAPT
p-PKR dimer phosphorylates SNCA
p-PKR dimer phosphorylates HIV tat
IKK complex is activated by PKR
p-PKR dimer phosphorylates PTPN2
p-PKR dimer phosphorylates SPHK1
p-PKR dimer phosphorylates PPP2R5A