Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Combined Automated Annotation using Multiple IEA Methods
Analyses of the regulatory mechanism and physiological roles of Pseudomonas aeruginosa OhrR, a transcription regulator and a sensor of organic hydroperoxides.
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OhrR binds the ohr and ohrR operators and represses their transcription.
"OhrR binds directly to the operators and represses transcription of these genes"
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Organic hydroperoxide oxidises OhrR, which loses operator binding and allows target gene expression.
"Exposure to an organic hydroperoxide leads to oxidation of OhrR and to subsequent structural changes that result in the loss of the repressor's ability to bind to the operators that allow expression of the target genes"
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An ohrR mutant is more resistant to organic hydroperoxides and shows reduced virulence in C. elegans.
"ohrR and ohr mutants show increased and decreased resistance to organic hydroproxides, respectively, compared to a parental strain"