Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic Gene Ontology annotation based on Rhea mapping
Combined Automated Annotation using Multiple IEA Methods
Characterizing the interactions between the two subunits of the p101/p110gamma phosphoinositide 3-kinase and their role in the activation of this enzyme by G beta gamma subunits.
Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.
The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner.
Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.
Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.
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p110γ autophosphorylates Ser1101; unlike p110β, this did not inhibit its lipid kinase activity under the tested conditions.
"Autophosphorylation sites of both PI3K isoforms were mapped to C-terminal serine residues of the catalytic p110 subunit (i.e. serine 1070 of p110 beta and serine 1101 of p110 gamma)."
Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma.
Cloning, expression, purification, and characterization of the human Class Ia phosphoinositide 3-kinase isoforms.
Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.
Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.
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Human recombinant p110γ, used as the PI3K comparator, generates PI3P, PI(3,4)P2 and PIP3 from the corresponding lipid substrates.
"Whereas yeast and mammalian IPMKs form only a single product, PI3K also forms PI(3,4)P 2 and PI (3)P in addition to PI(3,4,5)P 3 when incubated with lipid extracts, consistent with previous reports ( 9 )."
PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?
Targeting phosphoinositide 3-kinase gamma to fight inflammation and more.
Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.
Isoform selective phosphoinositide 3-kinase gamma and delta inhibitors and their therapeutic potential.
Cardiac regulation by phosphoinositide 3-kinases and PTEN.
Twice upon a time: PI3K's secret double life exposed.
Defining the membrane proteome of NK cells.
Network organization of the human autophagy system.
Regulation and roles of PI3Kβ, a major actor in platelet signaling and functions.
A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells.
Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.
PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.
New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Function, Regulation and Biological Roles of PI3Kγ Variants.
Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.
Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase.
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane
PI3K phosphorylates PIP2 to PIP3
PI3K inhibitors block PI3K catalytic activity
CD28 bound PI3K phosphorylates PIP2 to PIP3
Gbeta:gamma recruits PI3K gamma
G beta:gamma activated PI3Kgamma converts PIP2 to PIP3
GPVI stimulates PI3K beta, gamma
PI3K alpha, beta, gamma convert PIP2 to PIP3
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K
EPOR-associated PI3K phosphorylates PIP2 to PIP3
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K