Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Combined Automated Annotation using Multiple IEA Methods

Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.

The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.

Generation of functional multipotent adult stem cells from GPR125+ germline progenitors.

Gpr125 modulates Dishevelled distribution and planar cell polarity signaling.

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes.

Elevated G-Protein Receptor 125 (GPR125) Expression Predicts Good Outcomes in Colorectal Cancer and Inhibits Wnt/β-Catenin Signaling Pathway.

Arrestin-independent constitutive endocytosis of GPR125/ADGRA3.

GPR125 positively regulates osteoclastogenesis potentially through AKT-NF-κB and MAPK signaling pathways.

GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates epithelial apicobasal polarity.

Quantitative fragmentomics allow affinity mapping of interactomes.

Loss of Adgra3 causes obstructive azoospermia with high penetrance in male mice.

High incidence of imperforate vagina in ADGRA3-deficient mice.

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis.

Complex G-protein signaling of the adhesion GPCR, ADGRA3.