Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Analysis of the promoter of the cudA gene reveals novel mechanisms of Dictyostelium cell type differentiation.
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STATa directly activates cudA transcription in prestalk cells by binding an essential site in the prestalk-specific region of the cudA promoter.
"Dd-STATa appears therefore to serve as a direct activator of cudA transcription in prestalk cells"
A new family of transcription factors.
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CudA binds in vivo to the cotC prespore promoter and is required for prespore-specific gene expression.
"CudA, a nuclear protein required for Dictyostelium prespore-specific gene expression, binds in vivo to the promoter of the cotC prespore gene."
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CudA binds an interrupted dyad DNA element and forms a homodimer, consistent with a symmetrical binding site.
"consistent with a symmetrical binding site, CudA forms a homodimer in the yeast two-hybrid system"
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CudA defines a new family of transcription factors whose conserved core region is a presumptive DNA-binding domain related to plant STAT-like proteins.
"This region, the presumptive DNA-binding domain, is similar in sequence to domains in two Arabidopsis proteins and one Oryza protein."
Identification of a target for CudA, the transcription factor which directs formation of the Dictyostelium tip organiser.
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CudA acts as a specific transcription factor in prespore cells and in the tip-organiser.
"CudA is a nuclear protein which is expressed in prespore cells where it acts as a specific transcription factor."
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CudA directly activates the tip-organiser gene expl7; expl7 is not expressed in cudA-null slugs and CudA binds the expl7 promoter.
"there is no detectable expression of expl7 in cudA null slugs"
Leaps and lulls in the developmental transcriptome of Dictyostelium discoideum.
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cudA transcript is sharply up-regulated at ~16 h, coincident with the slug/culmination phase of development.
"At 16 h, cudA and mybE were up-regulated sharply"
Regulation of ecmF gene expression and genetic hierarchy among STATa, CudA, and MybC on several prestalk A-specific gene expressions in Dictyostelium.
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cudA is the only verified up-regulated target gene of STATa, and CudA directly activates expL7 expression in prestalk cells.
"The only verified upregulated target gene of STATa is cudA gene; CudA directly activates expL7 gene expression in prestalk cells."
cudA: a Dictyostelium gene with pleiotropic effects on cellular differentiation and slug behaviour.
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cudA encodes a nucleoplasmic protein essential for normal culmination.
"The Dictyostelium cudA gene encodes a nucleoplasmic protein that is essential for normal culmination."
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cudA-null cells are defective in both stalk and spore formation, indicating a role on both differentiation pathways.
"cudA- mutant cells are indeed defective in both stalk and spore formation."
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cudA-null slugs fail to enter culmination and continue migrating under conditions where wild-type slugs culminate.
"the slugs formed by cudA- cells continue to migrate under environmental conditions where normal slugs culminate immediately"