Exact emitted record, retrieved 2026-09-10T14:34:33.345768+00:00.
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer
UNC (CS 1). The paragraph correctly describes SDHAF2-mediated SDHA maturation at the gene level. The statements about TCA and respiratory chemistry describe the SDH complex, not intrinsic SDHAF2 catalysis. The selected product retains its mitochondrial targeting sequence but lacks the intact reference C-terminal region; whether it supports flavinylation or complex-II assembly is unresolved. PMID:38569044(https://pubmed.ncbi.nlm.nih.gov/38569044/); sequence comparison.
The assessment concerns the selected accession A0A494B8X4. Other emitted outputs and evidence context.