Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein.

A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling.

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.

Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor.

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.

Purification and characterization of the human gamma-secretase complex.

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

Defining the membrane proteome of NK cells.

Interactome mapping suggests new mechanistic details underlying Alzheimer's disease.

Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.

Specific combinations of presenilins and Aph1s affect the substrate specificity and activity of γ-secretase.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560.

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease.

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation.

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin.

Cleavage of ERBB4m80 by gamma-scretase complex

gamma-secretase cleaves the p75NTR transmembrane domain

gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6

NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants

gamma-secretase cleaves EPHB2

NEXT3 is cleaved to produce NICD3

Gamma-secretase cleaves YBX1:NOTCH3

TGFBR3(784-851) degradation

Gamma-secretase complex cleaves mNEXT2

Gamma-secretase cleaves Notch4