Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
A conserved family of prolyl-4-hydroxylases that modify HIF.
Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing.
OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha.
Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.
IOP1, a novel hydrogenase-like protein that modulates hypoxia-inducible factor-1alpha activity.
The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability.
Erythrocytosis-associated HIF-2alpha mutations demonstrate a critical role for residues C-terminal to the hydroxylacceptor proline.
Role of the intracellular localization of HIF-prolyl hydroxylases.
Cellular oxygen sensing: Importins and exportins are mediators of intracellular localisation of prolyl-4-hydroxylases PHD1 and PHD2.
Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen.
Studies on the reaction of nitric oxide with the hypoxia-inducible factor prolyl hydroxylase domain 2 (EGLN1).
The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis.
Elucidating novel hepatitis C virus-host interactions using combined mass spectrometry and functional genomics approaches.
SIRT2 regulates tumour hypoxia response by promoting HIF-1α hydroxylation.
A genetic mechanism for Tibetan high-altitude adaptation.
Myeloid translocation gene-16 co-repressor promotes degradation of hypoxia-inducible factor 1.
1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction.
Mutations in EPAS1 in congenital heart disease in Tibetans.
Quantitative fragmentomics allow affinity mapping of interactomes.
SM-20 is a novel 40-kd protein whose expression in the arterial wall is restricted to smooth muscle.
Proteasome proteolyzes ub-HIF-alpha
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
Enhancement of angiogenesis through stabilization of hypoxia-inducible factor-1 by silencing prolyl hydroxylase domain-2 gene.
Selective inhibition of hypoxia-inducible factor (HIF) prolyl-hydroxylase 1 mediates neuroprotection against normoxic oxidative death via HIF- and CREB-independent pathways.
Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases.
Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D.
Regulation of ATP13A2 via PHD2-HIF1α Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease.
The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A.
Subcellular - EGLN1 - The Human Protein Atlas
EGLN1 source evidence and access guide
EGLN1 reproducible database and PDZ-table evidence