Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Provides electronic endosome membrane, early endosome membrane, recycling endosome membrane, and Golgi membrane localizations for STX12 based on UniProt subcellular-location vocabulary, consistent with experimental IDA/ISS evidence.
Gene Ontology annotation based on curation of immunofluorescence data
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Pallidin is a component of a multi-protein complex involved in the biogenesis of lysosome-related organelles.
Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells.
The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.
Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation.
A proteome-scale map of the human interactome network.
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Rolland et al. HI-II-14 proteome-scale yeast two-hybrid map reports an STX12 protein-protein interaction. High-throughput dataset; only bare protein-binding evidence, not a specific molecular function.
"A proteome-scale map of the human interactome network."
The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs).
Architecture of the human interactome defines protein communities and disease networks.
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Huttlin et al. BioPlex 2.0 affinity-purification-mass-spectrometry human interactome records STX12 co-purifying partners. High-throughput dataset; only bare protein-binding evidence, not a specific molecular function.
"Architecture of the human interactome defines protein communities and disease networks."
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
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Fragoza et al. yeast-two-hybrid screen of population variants includes STX12 interaction data. High-throughput dataset; only bare protein-binding evidence, not a specific molecular function.
"Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations."
A reference map of the human binary protein interactome.
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Luck et al. HuRI reference binary interactome (yeast two-hybrid) records STX12 interactions. High-throughput dataset; only bare protein-binding evidence, not a specific molecular function.
"A reference map of the human binary protein interactome."
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
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Huttlin et al. BioPlex 3.0 dual (HEK293T/HCT116) affinity-purification-mass-spectrometry interactome records STX12 interactions. High-throughput dataset; only bare protein-binding evidence, not a specific molecular function.
"Dual proteome-scale networks reveal cell-specific remodeling of the human interactome."
OpenCell: Endogenous tagging for the cartography of human cellular organization.
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OpenCell endogenous split-mNeonGreen tagging with live-cell imaging and IP-MS records STX12 subcellular localization and interaction partners at endogenous levels. Supports vesicular/endosomal localization; high-throughput screen provides only bare protein-binding evidence for the interaction rows.
"OpenCell: Endogenous tagging for the cartography of human cellular organization."
Multimodal cell maps as a foundation for structural and functional genomics.
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Schaffer et al. multimodal cell-map integration of BioPlex/OpenCell/CellMap data reports STX12 community membership. High-throughput dataset; provides only bare protein-binding-level evidence, not a specific molecular function.
"Multimodal cell maps as a foundation for structural and functional genomics."
UniProt entry for STX12 (Q86Y82)
Local curation notes for STX12