Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila.
The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways.
Sending and receiving the hedgehog signal: control by the Drosophila Gli protein Cubitus interruptus.
The wingless signaling pathway is directly involved in Drosophila heart development.
Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.
Expression patterns of developmental genes reveal segment and parasegment organization of D. melanogaster genital discs.
The role of segment polarity genes during early oogenesis in Drosophila.
Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling.
Hedgehog signaling regulates transcription through cubitus interruptus, a sequence-specific DNA binding protein.
Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor.
Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2.
Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway.
Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway.
Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus.
Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signaling.
The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels.
Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo.
Identification of a tetrameric hedgehog signaling complex.
Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation.
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus.
An absolute requirement for Cubitus interruptus in Hedgehog signaling.
Hedgehog acts as a somatic stem cell factor in the Drosophila ovary.
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the kinesin-related protein Costal2.
A positive role for Patched in Hedgehog signaling revealed by the intracellular trafficking of Sex-lethal, the Drosophila sex determination master switch.
A protein interaction map of Drosophila melanogaster.
The negative regulator of Gli, Suppressor of fused (Sufu), interacts with SAP18, Galectin3 and other nuclear proteins.
Multiple Cos2/Ci interactions regulate Ci subcellular localization through microtubule dependent and independent mechanisms.
Opposing inputs by Hedgehog and Brinker define a stripe of hairy expression in the Drosophila leg imaginal disc.
Homeotic proboscipedia function modulates hedgehog-mediated organizer activity to pattern adult Drosophila mouthparts.
Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.
The role of Dpp signaling in maintaining the Drosophila anteroposterior compartment boundary.
Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye.
Hox-controlled reorganisation of intrasegmental patterning cues underlies Drosophila posterior spiracle organogenesis.
Phosphorylation by double-time/CKIepsilon and CKIalpha targets cubitus interruptus for Slimb/beta-TRCP-mediated proteolytic processing.
Processing of the Drosophila hedgehog signaling effector Ci-155 to the repressor Ci-75 is mediated by direct binding to the SCF component Slimb.
Regulation of the Drosophila transcription factor, Cubitus interruptus, by two conserved domains.
Regulation of Ci and Su(fu) nuclear import in Drosophila.
Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus.
A hedgehog-induced BTB protein modulates hedgehog signaling by degrading Ci/Gli transcription factor.
Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors.
Regulation of Ci-SCFSlimb binding, Ci proteolysis, and hedgehog pathway activity by Ci phosphorylation.
The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling.
The role of Parafibromin/Hyrax as a nuclear Gli/Ci-interacting protein in Hedgehog target gene control.
Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase.
Interaction between Ataxin-2 Binding Protein 1 and Cubitus-interruptus during wing development in Drosophila.
Odd paired transcriptional activation of decapentaplegic in the Drosophila eye/antennal disc is cell autonomous but indirect.
Costal 2 interactions with Cubitus interruptus (Ci) underlying Hedgehog-regulated Ci processing.
Hedgehog targets in the Drosophila embryo and the mechanisms that generate tissue-specific outputs of Hedgehog signaling.
Sequential phosphorylation of smoothened transduces graded hedgehog signaling.
Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus.
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation.
Distinct phosphorylations on kinesin costal-2 mediate differential hedgehog signaling strength.
Functional genomic analyses of two morphologically distinct classes of Drosophila sensory neurons: post-mitotic roles of transcription factors in dendritic patterning.
Structural insight into the mutual recognition and regulation between Suppressor of Fused and Gli/Ci.
Suppressor of fused impedes Ci/Gli nuclear import by opposing Trn/KapĪ²2 in Hedgehog signaling.
Hedgehog-induced phosphorylation by CK1 sustains the activity of Ci/Gli activator.
Bacterial uracil modulates Drosophila DUOX-dependent gut immunity via Hedgehog-induced signaling endosomes.
Multisite interaction with Sufu regulates Ci/Gli activity through distinct mechanisms in Hh signal transduction.
A Comparison of Ci/Gli Activity as Regulated by Sufu in Drosophila and Mammalian Hedgehog Response.
Ci antagonizes Hippo signaling in the somatic cells of the ovary to drive germline stem cell differentiation.
Phosphorylation of Ci/Gli by Fused Family Kinases Promotes Hedgehog Signaling.
Dissection of the microRNA Network Regulating Hedgehog Signaling in Drosophila.
Dose-dependent phosphorylation and activation of Hh pathway transcription factors.
Tai/NCOA2 suppresses the Hedgehog pathway by directly targeting the transcription factor Ci/GLI.
Morphogen-induced kinase condensates transduce Hh signal by allosterically activating Gli.
Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
CI transports from the cytosol to the nucleus
Phosphorylation of SMO by CKIalpha
Phosphorylation of CI by SGG
Further phosphorylation of CI by CKIalphaepsilon
Phosphorylation of CI by PKA-C1
CI activates transcription
Liberation of CI from SU(FU) repression
SLMB binds to and ubiquitinates phosphorylated CI
CI75 inhibits transcription
Autophosphorylated FU phosphorylates COS
Ubiquitinated and phosphorylated CI is partially degraded by the proteasome complex
Phosphorylation of CI by CKIalphaepsilon (CKIalpha/DCO)
Formation of the 'scaffold complex'
Phosphorylation of SMO by PKA-C1
CI75 transports from the cytosol to the nucleus
Dissociation of CI from COS
Formation of the CI:SU(FU) complex
Phosphorylated SMO changes conformation and is activated
Ubiquitinated CI is degraded by the proteasome complex
RDX binds to and ubiquitinates CI