Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000108

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

GO_REF:0000117

Electronic Gene Ontology annotations created by ARBA machine learning models

PMID:14557246

AIP is a mitochondrial import mediator that binds to both import receptor Tom20 and preproteins.

PMID:17329248

Phosphodiesterase 2A forms a complex with the co-chaperone XAP2 and regulates nuclear translocation of the aryl hydrocarbon receptor.

PMID:19375531

XAP2 inhibits glucocorticoid receptor activity in mammalian cells.

PMID:20029029

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.

PMID:21170051

Mixed Hsp90-cochaperone complexes are important for the progression of the reaction cycle.

PMID:21903422

Mapping a dynamic innate immunity protein interaction network regulating type I interferon production.

PMID:22113938

A bead-based approach for large-scale identification of in vitro kinase substrates.

PMID:23300914

Structure of the TPR domain of AIP: lack of client protein interaction with the C-terminal α-7 helix of the TPR domain of AIP is sufficient for pituitary adenoma predisposition.

PMID:25036637

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.

PMID:28514442

Architecture of the human interactome defines protein communities and disease networks.

PMID:28634279

In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism.

PMID:31980649

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

PMID:33961781

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

PMID:35271311

OpenCell: Endogenous tagging for the cartography of human cellular organization.

PMID:8972861

XAP2, a novel hepatitis B virus X-associated protein that inhibits X transactivation.

PMID:9447995

Hepatitis B virus X-associated protein 2 is a subunit of the unliganded aryl hydrocarbon receptor core complex and exhibits transcriptional enhancer activity.

Reactome:R-HSA-8936849

AHR:2xHSP90:AIP:PTGES3 binds TCDD

Reactome:R-HSA-8937169

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 translocates from cytosol to nucleoplasm

Reactome:R-HSA-8937191

AHR:TCDD:2xHSP90AB1:AIP:PTGES3 dissociates

Reactome:R-HSA-8950201

Expression of Aryl Hydrocarbon receptor-interacting protein

DOI:10.1038/s41467-022-34773-w

Cryo-EM structure of the agonist-bound Hsp90-XAP2-AHR cytosolic complex

High-resolution cryo-EM structure of the human agonist-bound AHR cytosolic complex with Hsp90 and XAP2/AIP reveals AIP acting as a structural brace associated with the Hsp90 dimer and the AHR client; the Hsp90 C-terminal MEEVD motif docks into the TPR domain of AIP, consistent with canonical TPR-mediated recruitment of HSP90 co-chaperones.

DOI:10.18632/oncotarget.24183

Multi-chaperone function modulation and association with cytoskeletal proteins are key features of the function of AIP in the pituitary gland

Proteomic analysis shows AIP co-localizes with HSPA9 in the mitochondrial chaperone network, consistent with broader chaperone-network associations beyond the AHR complex.

DOI:10.1586/eem.10.42

Role of the aryl hydrocarbon receptor-interacting protein in familial isolated pituitary adenoma

AIP interacts with phosphodiesterases PDE4A5 and PDE2A3, linking it to localized cAMP regulation and potentially to modulation of AHR nuclear translocation and pituitary tumor biology.

DOI:10.1038/s41574-023-00948-8

Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 1, general recommendations

Among childhood-onset GH-secreting pituitary tumours presenting as gigantism, AIP mutations account for approximately 29% of cases; for macroprolactinomas presenting before age 20, the genetic aetiology includes approximately 9% AIP and 5% MEN1.

DOI:10.1093/ejendo/lvad148

Genetic testing in prolactinomas - a cohort study

In sporadic isolated macroprolactinomas diagnosed at age 30 or younger, the germline pathogenic/likely pathogenic variant prevalence was 4.3% overall, with 1.9% AIP; sporadic macroprolactinoma diagnosed before age 18 had approximately 9-fold higher odds of carrying a germline mutation than diagnosis at 18-30.

DOI:10.3389/fendo.2023.1098367

AIP gene germline variants in adult Polish patients with apparently sporadic pituitary macroadenomas

Penetrance among AIP variant carriers is incomplete and variable, with reported estimates ranging from approximately 12-30%, and some variants/families as low as approximately 6%.

file:human/AIP/AIP-deep-research-falcon.md

Falcon deep research for human AIP

Falcon synthesis supports AIP as a cytosolic HSP90/AHR co-chaperone and scaffold that stabilizes client-protein complexes and lacks PPIase catalytic activity.

file:projects/PROTEOSTASIS/reports/pn_projection/pn_projected_gene_go_summary.tsv

Proteostasis PN projected gene-GO summary

PN projection reports AIP to GO:0031072 heat shock protein binding through the HSP70-HSP90 joint co-chaperone branch and to GO:0003755 peptidyl-prolyl cis-trans isomerase activity through the FKBP-type PPIase branch.