Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on inter-ontology links
Function and evolution of a mosquito salivary protein family
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D7 short proteins bind serotonin, histamine and norepinephrine with high affinity
"four of these five short D7 proteins and the D7 long form bind serotonin with high affinity, as well as histamine and norepinephrine"
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Scavenging host amines antagonizes vasoconstriction and platelet aggregation
"Scavenging of host amines would antagonize their vasoconstrictor, platelet-aggregating, and pain-inducing properties"
Trapping cDNAs encoding secreted proteins from the salivary glands of the malaria vector Anopheles gambiae
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D7-related genes were identified in A. gambiae salivary glands
"Fragments showing a high degree of similarity to D7 and apyrase, two salivary gland-specific genes previously found in Aedes aegypti, were identified"
A cluster of four D7-related genes is expressed in the salivary glands of the African malaria vector Anopheles gambiae
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D7r genes are expressed in adult female salivary glands
"Four genes expressed in the Anopheles gambiae adult female salivary glands and similar in sequence to the Aedes aegypti D7 gene were identified"
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D7r proteins are secreted into host during blood feeding
"The deduced proteins contain secretory signals and they are probably injected by the mosquito into the host with the saliva during blood feeding"
UniProt entry for D7R1_ANOGA
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D7r1 modulates blood feeding by binding host mediators
"Modulates blood feeding of female mosquitoes on vertebrate species by binding and sequestering different mediators involved in the host response"
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Binds serotonin and histamine
"Binds serotonin and histamine"
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Increases blood clotting time
"Increases blood clotting time"
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Expressed in female salivary gland
"Female salivary gland"
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Protein is secreted
"SUBCELLULAR LOCATION: Secreted"
Deep research review of D7r1 function and evolution
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D7 proteins function as kratagonists that scavenge host signaling molecules
"D7 proteins are among the most abundant mosquito salivary proteins and function as kratagonists - high-affinity scavengers of host small-molecule inflammatory and hemostatic mediators"
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Short-form D7s bind biogenic amines
"Short-form D7s (including D7r1) predominantly bind biogenic amines (serotonin/5-HT, histamine, epinephrine/norepinephrine)"
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D7r1 is secreted in saliva during feeding
"D7r1 is produced in adult female salivary glands and secreted in saliva at the skin interface during probing/feeding"