Gene Ontology annotation based on Enzyme Commission mapping
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
A Caenorhabditis elegans Parkin mutant with altered solubility couples alpha-synuclein aggregation to proteotoxic stress.
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PDR-1 is the C. elegans Parkin ortholog with E3 ubiquitin ligase activity
"PDR-1 protein physically associates and cooperates with a conserved degradation machinery to mediate ubiquitin conjugation"
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PDR-1 physically associates with ubiquitin conjugating enzymes
"the corresponding truncated protein PDR-1(Deltaaa24-247) aggregates in cell culture, but still interacts with its ubiquitylation co-enzymes"
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Mutant PDR-1 with altered solubility causes proteotoxic stress sensitivity
"an in-frame deletion variant with altered solubility and intracellular localization properties is hypersensitive toward different proteotoxic stress conditions"
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
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Loss of pdr-1 increases vulnerability to mitochondrial complex I inhibitors
"C. elegans lines with these genetic changes were more vulnerable than nontransgenic nematodes to mitochondrial complex I inhibitors, including rotenone, fenperoximate, pyridaben, or stigmatellin"
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pdr-1 deletion shows similar patterns to alpha-synuclein expression and DJ-1 knockdown
"expressing alpha-synuclein, deleting parkin (K08E3.7), or knocking down DJ-1 (B0432.2) or parkin produces similar patterns of pharmacological vulnerability and rescue"
PDR-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in Caenorhabditis elegans.
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PDR-1 ubiquitinates CED-10/Rac1 for proteasomal degradation
"No CED-10 immunostaining was observed when ubiquitin-K48R was used in pull-down assays, indicating that PDR-1 ubiquitylated CED-10 through K48 ubiquitin linkages"
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PDR-1 negatively regulates apoptotic cell engulfment
"Our genetic and biochemical studies indicate that PDR-1 inhibits apoptotic cell engulfment and DTC migration by ubiquitylating CED-10 for degradation"
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PDR-1 affects distal tip cell migration through CED-10 regulation
"However, mutations of pdr-1 decreased the percentage of gonadal morphology defects in the two ced-10 alleles tested"
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The amount of CED-10 is increased in the absence of PDR-1
"The amount of CED-10 is increased in the absence of PDR-1"
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.
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PDR-1 functions in the PINK-1/PDR-1 mitophagy pathway
"mitophagy, a selective type of autophagy targeting mitochondria for degradation, interfaces with mitochondrial biogenesis to regulate mitochondrial content and longevity"
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DCT-1 is a key mediator of mitophagy downstream of PDR-1
"We find that DCT-1 is a key mediator of mitophagy and longevity assurance under conditions of stress in C. elegans"
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Impairment of mitophagy compromises stress resistance
"Impairment of mitophagy compromises stress resistance and triggers mitochondrial retrograde signalling through the SKN-1 transcription factor"
A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans.
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PDR-1 functions with PINK-1 in mitochondrial quality control
"GSH protects against the toxicity of MG132 and can compensate for the combined loss of both pink-1 and the E3 ligase pdr-1, a Parkin homolog"
Deep research review of pdr-1 gene function
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PDR-1 is primarily cytosolic with enrichment at autophagy-lysosomal compartments
"Reporter and biochemical data place PDR-1 primarily in the cytosol with enriched compartmentalization to autophagy-lysosomal structures"
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PDR-1 functions in the conserved PINK-1-PDR-1 mitophagy pathway
"PDR-1 acts downstream of PINK-1 in canonical mitophagy, cooperating with receptors such as DCT-1 to ubiquitinate OMM substrates"